Occlusal stimuli influence on the expression of IGF-1 and the IGF-1 receptor in the rat periodontal ligament

被引：0
作者：
Termsuknirandorn, Saewadee [1 ]
Hosomichi, Jun [1 ]
Soma, Kunimichi [1 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch, Div Oral Hlth Sci, Dept Orofacial Dev & Funct,Bunkyo Ku, Tokyo 1138549, Japan
来源：
ANGLE ORTHODONTIST | 2008年 / 78卷 / 04期
关键词：
periodontal ligament; occlusal stimuli; IGIF-1; IGF-1; receptor; cell proliferation;
D O I：
10.2319/0003-3219(2008)078[0610:OSIOTE]2.0.CO;2
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective: To test the hypothesis that hypofunction/recovered occlusal function has no effect on the changes in insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expressions and cell proliferation of periodontal ligament (PDL) cells. Materials and Methods: To produce occlusal hypofunction, the appliances were attached to the rats' maxillary and mandibular incisors. Subsequently, occlusal contact of the molar area was thoroughly recovered by removal of the appliances. Results: In periodontal sections, localization of IGF-1, the IGF-1 receptor, and proliferating cell nuclear antigen (PCNA) immunoreactive cells was significantly more expressed in the control group compared with the hypofunctional group (P <.01). In addition, after the recovery of the occlusion, IGF-1, IGF-1 receptor, and PCNA were detected significantly much more than in the hypofunction group (P <.01). Conclusion: The hypothesis was rejected. This study suggests that occlusal stimuli induce cell proliferation of PDL cells by increasing IGF-1 and IGF-1 receptor expression.
引用
收藏
页码：610 / 616
页数：7
相关论文
共 28 条
[1]   Controlling IGF-receptor function: A possible strategy for tumor therapy [J].
Baserga, R .
TRENDS IN BIOTECHNOLOGY, 1996, 14 (05) :150-152
[2]   THE EFFECT OF INSULIN-LIKE GROWTH FACTOR-I AND HUMAN GROWTH-HORMONE ON PERIODONTAL-LIGAMENT FIBROBLAST MORPHOLOGY, GROWTH-PATTERN, DNA-SYNTHESIS, AND RECEPTOR-BINDING [J].
BLOM, S ;
HOLMSTRUP, P ;
DABELSTEEN, E .
JOURNAL OF PERIODONTOLOGY, 1992, 63 (12) :960-968
[3]   THE INSULIN-LIKE GROWTH-FACTORS [J].
COHICK, WS ;
CLEMMONS, DR .
ANNUAL REVIEW OF PHYSIOLOGY, 1993, 55 :131-153
[4]  
COHN S. A., 1965, ARCH ORAL BIOL, V10, P909, DOI 10.1016/0003-9969(65)90084-1
[5]   DISUSE ATROPHY OF PERIODONTIUM IN MICE FOLLOWING PARTIAL LOSS OF FUNCTION [J].
COHN, SA .
ARCHIVES OF ORAL BIOLOGY, 1966, 11 (01) :95-&
[6]   GROWTH-HORMONE PULSATILITY AND THE ENDOCRINE MILIEU DURING SEXUAL-MATURATION IN MALE AND FEMALE RATS [J].
GABRIEL, SM ;
RONCANCIO, JR ;
RUIZ, NS .
NEUROENDOCRINOLOGY, 1992, 56 (05) :619-628
[7]   Periodontal tissue engineering by growth factors [J].
Giannobile, WV .
BONE, 1996, 19 (01) :S23-S37
[8]   Immunohistochemical localization of components of the insulin-like growth factor system in human permanent teeth [J].
Goetz, Werner ;
Heinen, Michael ;
Lossdoerfer, Stefan ;
Jaeger, Andreas .
ARCHIVES OF ORAL BIOLOGY, 2006, 51 (05) :387-395
[9]   Immunohistochemical localization of components of the insulin-like growth factor-system in human deciduous teeth [J].
Götz, W ;
Krüger, U ;
Ragotzki, S ;
Lossdörfer, S ;
Jäger, A .
CONNECTIVE TISSUE RESEARCH, 2001, 42 (04) :291-+
[10]   Propulsive appliance stimulates, the synthesis of insulin-like growth factors I and II in the mandibular condylar cartilage of young rats [J].
Hajjar, D ;
Santos, MF ;
Kimura, ET .
ARCHIVES OF ORAL BIOLOGY, 2003, 48 (09) :635-642
123