Neuroprotective Effect of GK-2, a Dipeptide Mimetic of Nerve Growth Factor, during Experimental Focal Ischemia in Middle Cerebral Artery Basin

被引：0
作者：
Seredenin, S. B. [1 ]
Silachev, D. N.
Gudasheva, T. A. [1 ]
Pirogov, Yu. A. [2 ]
Isaev, N. K.
机构：
[1] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Moscow 109801, Russia
[2] Moscow MV Lomonosov State Univ, Training & Res Interfac Ctr Magnet Tomog & Spect, Moscow 117234, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 05期
关键词：
nerve growth factor mimetic; GK2; neuroprotection; cerebral ischemia; magnetic resonance tomography; STROKE; BRAIN;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Magnetic resonance tomography, staining with triphenyltetrazolium chloride, and tests for evaluation of functional disturbances " cylinder" and " limb stimulation" showed that daily intraperitoneal injection of dipeptide mimetic of nerve growth factor GK-2 (1 mg/kg) for 6 days to rats with experimental focal ischemia provoked by unilateral intravascular occlusion of a branch of the middle cerebral artery signifi cantly improved neurological defi cit and decreased the infarction area.
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收藏
页码：584 / 587
页数：4
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