Association between the promoter region of serotonin transporter polymorphisms and recurrent aphthous stomatitis: A meta-analysis

被引：15

作者：

Lu, Yuanyuan ^{[1
]}

Wang, Wenbing ^{[2
]}

Ding, Xianhui ^{[2
]}

Shi, Xiaolei ^{[2
]}

机构：

[1] Yijishan Hosp, Affiliated Hosp 1, Dept Radiotherapy, Wannan Med Coll, Wuhu 241000, Peoples R China

[2] Yijishan Hosp, Affiliated Hosp 1, Dept Neurol, Wannan Med Coll, Wuhu 241000, Peoples R China

来源：

ARCHIVES OF ORAL BIOLOGY | 2020年 / 109卷

基金：

中国国家自然科学基金;

关键词：

Recurrent aphthous stomatitis; 5-HTTLPR; Polymorphism; Association; Meta-analysis; GENE POLYMORPHISM;

D O I：

10.1016/j.archoralbio.2019.104555

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives: To assess the association between the promoter region of serotonin transporter (5-HTTLPR) gene polymorphism and recurrent aphthous stomatitis (RAS) occurrence. Designs: We performed the meta-analysis to determine the potential association between 5-HTTLPR polymorphism and RAS. We retrieved revelant studies from the PubMed, Scopus, Embase, Web of Science and Cochrane Library databases up to January 2019. Data were analyzed for odd ratios with 95% confidence intervals using Revman 5.3 software. Results: There were 4 studies in the meta-analysis, which included 291 RAS cases and 286 controls. It indicated a substantially augmented threat of RAS with respect to S vs. L (P = 0.005), SS vs. LL + LS (P < 0.0001) and SS vs. LL models (P < 0.00001), respectively. No heterogeneity was found between studies in all comparisons. Conclusions: The current meta-analysis provides evidence to prove the association between 5-HTTLPR polymorphism and RAS. Further studies should be performed to clarify the biochemical function and pathological role of 5-HTTLPR in the risk of RAS.

引用

页数：6

共 22 条

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