Semaphorin 3A: Is a key player in the pathogenesis of asthma

被引：20
作者：
Cozacov, Ronen [1 ]
Halasz, Katlin [1 ]
Haj, Tharwat [1 ]
Vadasz, Zahava [1 ]
机构：
[1] Technion, Rappaport Fac Med, Bnai Zion Med Ctr, Div Allergy & Clin Immunol, Haifa, Israel
来源：
CLINICAL IMMUNOLOGY | 2017年 / 184卷
关键词：
CELLS;
D O I：
10.1016/j.clim.2017.05.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune semaphorins are key players in regulating immune mediated inflammation. Semaphorin3A (sema3A) a secreted and membrane bound member of this family, is well reported for its properties in maintaining self-tolerance. Semaphorin3A was recognized to be a marker for T-regulatory cells (Tregs), and as such is a useful tool for assessing the status of these cells in preventing immune mediated diseases. This study was designed aiming to evaluate how sema3A is possibly involved in bronchial asthma. Here, we found sema3A serum levels and the expression of sema3A on Tregs significantly lower in patients with moderate to severe asthma when compared to healthy individuals. Co-culture of condition medium with 2 mcg/ml of recombinant human sema3A with CD4+ T cells, increased the expression of FoxP3 in Tregs, suggesting sema3A a potent immune regulator of inflammation including that of asthma. Further in-vivo studies will better establish the beneficial effect of sema3A in regulating inflammation in asthma. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：70 / 72
页数：3
相关论文
共 12 条
[1]   Interplay of T Helper 17 Cells with CD4(+) CD25(high) FOXP3(+) Tregs in Regulation of Allergic Asthma in Pediatric Patients [J].
Agarwal, Amit ;
Singh, Meenu ;
Chatterjee, B. P. ;
Chauhan, Anil ;
Chakraborti, Anuradha .
INTERNATIONAL JOURNAL OF PEDIATRICS, 2014, 2014
[2]   The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis [J].
Catalano, Alfonso .
JOURNAL OF IMMUNOLOGY, 2010, 185 (10) :6373-6383
[3]   Decreased CTLA4+ and Foxp3+ CD25highCD4+ Cells in Induced Sputum from Patients with Mild Atopic Asthma [J].
Kawayama, Tomotaka ;
Matsunaga, Kazuko ;
Kaku, Yoichiro ;
Yamaguchi, Kyoko ;
Kinoshita, Takashi ;
O'Byrne, Paul M. ;
Hoshino, Tomoaki .
ALLERGOLOGY INTERNATIONAL, 2013, 62 (02) :203-213
[4]   Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization [J].
Lepelletier, Yves ;
Moura, Ivan Cruz ;
Hadj-Slimane, Reda ;
Renand, Amedee ;
Fiorentino, Susana ;
Baudell, Cedric ;
Shirvan, Anat ;
Barzilai, Ari ;
Hermine, Olivier .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (07) :1782-1793
[5]   Neuroimmune semaphorin 4A as a drug and drug target for asthma [J].
Mogie, G. ;
Shanks, K. ;
Nkyimbeng-Takwi, E. H. ;
Smith, E. ;
Davila, E. ;
Lipsky, M. M. ;
DeTolla, L. J. ;
Keegan, A. D. ;
Chapoval, S. P. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2013, 17 (03) :568-575
[6]   The role of immune semaphorins in multiple sclerosis [J].
Okuno, Tatsusada ;
Nakatsuji, Yuji ;
Kumanogoh, Atsushi .
FEBS LETTERS, 2011, 585 (23) :3829-3835
[7]   Regulatory T cells and asthma [J].
Robinson, D. S. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (09) :1314-1323
[8]   Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis [J].
Sawaki, Haruna ;
Nakamura, Fumio ;
Aihara, Michiko ;
Nagashima, Yoji ;
Komori-Yamaguchi, Junko ;
Yamashita, Naoya ;
Nakazawa, Masatoshi ;
Goshima, Yoshio ;
Ikezawa, Zenro .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 117 (01) :34-44
[9]   Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor [J].
Smith, Elizabeth P. ;
Shanks, Kathleen ;
Lipsky, Michael M. ;
DeTolla, Louis J. ;
Keegan, Achsah D. ;
Chapoval, Svetlana P. .
BMC IMMUNOLOGY, 2011, 12
[10]   Semaphorin 3A-a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus [J].
Vadasz, Z. ;
Toubi, E. .
LUPUS, 2012, 21 (12) :1266-1270
12