The Numbers Needed to Treat and Harm (NNT, NNH) Statistics: What They Tell Us and What They Do Not

被引：46

作者：

Andrade, Chittaranjan ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India

来源：

JOURNAL OF CLINICAL PSYCHIATRY | 2015年 / 76卷 / 03期

关键词：

METAANALYSIS; EFFICACY; RISK; ANTIDEPRESSANT; DEPRESSION; DISORDER; BENEFIT; TRIALS;

D O I：

10.4088/JCP.15f09870

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Research papers and research summaries frequently present information in the form of derived statistics such as the number needed to treat (NNT) and the number needed to harm (NNH). These statistics are not always correctly understood by the reader. This article explains what NNT and NNH mean; presents a simple, nontechnical explanation for the calculation of the NNT; addresses the interpretation of the NNT; considers applications of the NNT; and discusses the limitations of this statistic. The NNH is also briefly considered. (C) Copyright 2015 Physicians Postgraduate Press, Inc.

引用

页码：E330 / E333

页数：4

共 15 条

[1]

Andrade C, 2002, CAN J PSYCHIAT, V47, P886

[2] A Primer on Confidence Intervals in Psychopharmacology [J].

Andrade, Chittaranjan .

JOURNAL OF CLINICAL PSYCHIATRY, 2015, 76 (02) :E228-E231

[3] Primary prevention of cardiovascular events in patients with major mental illness: a possible role for statins [J].

Andrade, Chittaranjan .

BIPOLAR DISORDERS, 2013, 15 (08) :813-823

[4]

Andrade C, 2012, J CLIN PSYCHIAT, V73, P1322, DOI [10.4088/JCP.12f08124, 10.4088/JCP.12f08248, 10.4088/JCP.12f07731, 10.4088/JCP.12f07726, 10.4088/JCP.12f07977, 10.4088/JCP.12f08054, 10.4088/JCP.12f07732]

[5] Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? [J].

Citrome, L. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2013, 67 (11) :1089-1104

[6] Relative vs. absolute measures of benefit and risk: what's the difference? [J].

Citrome, L. .

ACTA PSYCHIATRICA SCANDINAVICA, 2010, 121 (02) :94-102

[7] Aripiprazole monotherapy in the treatment of bipolar disorder: A meta-analysis [J].

Fountoulakis, Konstantinos N. ;

Vieta, Eduard ;

Schmidt, Frank .

JOURNAL OF AFFECTIVE DISORDERS, 2011, 133 (03) :361-370

[8] Misleading StatisticsThe Problems Surrounding Number Needed to Treat and Number Needed to Harm [J].

Jane L. Hutton .

Pharmaceutical Medicine, 2010, 24 (3) :145-149

[9] Treatment benefit and the risk of suicidality in multicenter, randomized, controlled trials of sertraline in children and adolescents [J].

March, JS ;

Klee, BJ ;

Kremer, CME .

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2006, 16 (1-2) :91-102

[10] The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials [J].

Mihaylova, B. ;

Emberson, J. ;

Blackwell, L. ;

Keech, A. ;

Simes, J. ;

Barnes, E. H. ;

Voysey, M. ;

Gray, A. ;

Collins, R. ;

Baigent, C. ;

de Lemos, J. ;

Braunwald, E. ;

Blazing, M. ;

Murphy, S. ;

Downs, J. R. ;

Gotto, A. ;

Clearfield, M. ;

Holdaas, H. ;

Gordon, D. ;

Davis, B. ;

Koren, M. ;

Dahlof, B. ;

Poulter, N. ;

Sever, P. ;

Knopp, R. H. ;

Fellstrom, B. ;

Holdaas, H. ;

Jardine, A. ;

Schmieder, R. ;

Zannad, F. ;

Goldbourt, U. ;

Kaplinsky, E. ;

Colhoun, H. M. ;

Betteridge, D. J. ;

Durrington, P. N. ;

Hitman, G. A. ;

Fuller, J. ;

Neil, A. ;

Wanner, C. ;

Krane, V. ;

Sacks, F. ;

Moye, L. ;

Pfeffer, M. ;

Hawkins, C. M. ;

Braunwald, E. ;

Kjekshus, J. ;

Wedel, H. ;

Wikstrand, J. ;

Barter, P. ;

Keech, A. .

LANCET, 2012, 380 (9841) :581-590

← 1 2 →