Oxytocin in dorsal hippocampus facilitates auditory fear memory extinction in rats

被引：13
作者：
Bazaz, Amir [1 ]
Ghanbari, Ali [2 ]
Vafaei, Abbas Ali [3 ]
Khaleghian, Ali [4 ]
Rashidy-Pour, Ali [2 ]
机构：
[1] Semnan Univ Med Sci, Student Res Comm, Semnan, Iran
[2] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran
[3] Semnan Univ Med Sci, Dept Physiol, Semnan, Iran
[4] Semnan Univ Med Sci, Dept Biochem, Semnan, Iran
来源：
NEUROPHARMACOLOGY | 2022年 / 202卷
关键词：
Oxytocin; Auditory fear conditioning; Hippocampus; Prefrontal cortex; Infralimbic; Brain-derived neurotrophic factor; PREFRONTAL CORTEX; CONDITIONED FEAR; BRAIN OXYTOCIN; SOCIAL FEAR; EXPRESSION; RECEPTOR; BDNF; AMYGDALA; NEURONS; STRESS;
D O I：
10.1016/j.neuropharm.2021.108844
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Fear extinction is impaired in some psychiatric disorders. Any treatment that facilitates the extinction of fear is a way to advance the treatment of related psychiatric disorders. Recent studies have highlighted the role of oxytocin (OT) in fear extinction, but the endogenous release of OT during fear extinction in the dorsal hippocampal (dHPC) is not clear. We investigated the release of OT during fear extinction and the role of the HPC medial prefrontal cortex (mPFC) circuit and BDNF in the effects of exogenous OT on auditory fear conditioning in male rats. We found that the release of endogenous OT in the dHPC is significantly increased during the fear extinction process as measured by the microdialysis method. Increased freezing response in the OT-treated rats compared to saline-treated rats showed that exogenous OT in the dHPC enhanced the fear extinction. Injection of BDNF antagonist (ANA-12) into the infralimbic (IL) blocked the effect of exogenous OT on the dHPC. Following OT injection, BDNF levels increased in the dHPC, ventral HPC, and IL cortex; but decreased in the prelimbic cortex (PL). Finally, OT microinjected into the dHPC significantly increased neural activity of pyramidal neurons of the CA1-vHPC and IL but decreased the neural activity in the PL cortex. Our findings strongly support that the dHPC endogenous OT plays a crucial role in enhancing fear extinction. It seems that the activation of the HPCmPFC pathway, and consequently, the release of BDNF in the IL cortex mediates the enhancing effects of OT on fear extinction.
引用
收藏
页数：13
相关论文
共 50 条
[31]   Post-retrieval oxytocin facilitates next day extinction of threat memory in humans [J].
Hu, Jingchu ;
Wang, Zijie ;
Feng, Xiaoyi ;
Long, Cheng ;
Schiller, Daniela .
PSYCHOPHARMACOLOGY, 2019, 236 (01) :293-301
[32]   Histone Acetylation in the Hippocampus and Fear Extinction [J].
Yamamoto, Shigeto ;
Morinobu, Shigeru ;
Fujita, Yosuke ;
Yamawaki, Shigeto .
BIOLOGICAL PSYCHIATRY, 2012, 72 (01) :2-3
[33]   The role of the dorsal and ventral hippocampus in fear and memory of a shock-probe experience [J].
McEown, Kristopher ;
Treit, Dallas .
BRAIN RESEARCH, 2009, 1251 :185-194
[34]   Activation of mineralocorticoid receptors facilitate the acquisition of fear memory extinction and impair the generalization of fear memory in diabetic animals [J].
Ribeiro, Thiago Oliari ;
Bueno-de-Camargo, Leticia Morais ;
Farias Waltrick, Ana Paula ;
de Oliveira, Amanda Ribeiro ;
Brandao, Marcus Lira ;
Munhoz, Carolina Demarchi ;
Zanoveli, Janaina Menezes .
PSYCHOPHARMACOLOGY, 2020, 237 (02) :529-542
[35]   The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory [J].
Mizuno, Ikumi ;
Matsuda, Shingo .
PHARMACOLOGICAL REPORTS, 2021, 73 (04) :984-1003
[36]   Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction [J].
Miyamoto, Daisuke ;
Mahmoud, Mahmoud Abdelmouti .
MOLECULAR BRAIN, 2024, 17 (01)
[37]   The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample [J].
Acheson, Dean ;
Feifel, David ;
de Wilde, Sofieke ;
Mckinney, Rebecca ;
Lohr, James ;
Risbrough, Victoria .
PSYCHOPHARMACOLOGY, 2013, 229 (01) :199-208
[38]   Extinction, applied after retrieval of auditory fear memory, selectively increases zinc-finger protein 268 and phosphorylated ribosomal protein. S6 expression in prefrontal cortex and lateral amygdala [J].
Tedesco, Vincenzo ;
Roquet, Rheall F. ;
DeMis, John ;
Chiamulera, Cristiano ;
Monfils, Marie-H. .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2014, 115 :78-85
[39]   The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus [J].
Wislowska-Stanek, Aleksandra ;
Lehner, Malgorzata ;
Tomczuk, Filip ;
Gawryluk, Aleksandra ;
Kolosowska, Karolina ;
Sulek, Anna ;
Krzasnik, Pawel ;
Sobolewska, Alicja ;
Wawer, Adriana ;
Plaznik, Adam ;
Skorzewska, Anna .
PHARMACOLOGICAL REPORTS, 2023, 75 (01) :119-127
[40]   Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction [J].
Bayer, Hugo ;
Hassell, James E. ;
Oleksiak, Cecily R. ;
Garcia, Gabriela M. ;
Vaughan, Hollis L. ;
Juliano, Vitor A. L. ;
Maren, Stephen .
NEUROPSYCHOPHARMACOLOGY, 2024, 49 (13) :1951-1957
12345