Roles of the actin cytoskeleton in aging and age-associated diseases

被引：55
作者：
Lai, Wing-Fu [1 ,2 ,3 ]
Wong, Wing-Tak [3 ]
机构：
[1] Shenzhen Univ, Sch Pharmaceut Sci, Shenzhen, Peoples R China
[2] Chinese Univ Hong Kong, Sch Life & Hlth Sci, Shenzhen, Peoples R China
[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2020年 / 58卷
关键词：
Actin; Aging; Cytoskeleton; Longevity; Tissue homeostasis; SMOOTH-MUSCLE ACTIN; ALDRICH-SYNDROME PROTEIN; CHRONOLOGICAL LIFE-SPAN; CELL-CYCLE PROGRESSION; HUMAN SKELETAL-MUSCLE; HIGH-THROUGHPUT; CENTROSOME SEPARATION; SHORTENING VELOCITY; GENE-EXPRESSION; OLIGODENDROCYTE DIFFERENTIATION;
D O I：
10.1016/j.arr.2020.101021
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The integrity of the cytoskeleton is essential to diverse cellular processes such as phagocytosis and intracellular trafficking. Disruption of the organization and dynamics of the actin cytoskeleton leads to age-associated symptoms and diseases, ranging from cancer to neurodegeneration. In addition, changes in the integrity of the actin cytoskeleton disrupt the functioning of not only somatic and stem cells but also gametes, resulting in aberrant embryonic development. Strategies to preserve the integrity and dynamics of the cytoskeleton are, therefore, potentially therapeutic to age-related disorders. The objective of this article is to revisit the current understanding of the roles played by the actin cytoskeleton in aging, and to review the opportunities and challenges for the transition of basic research into intervention development. It is hoped that, with the snapshot of evidence regarding changes in actin dynamics with advanced age, insights into future research directions can be attained.
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页数：12
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