Integrin-mediated function of Rab GTPases in cancer progression

被引：90
作者：
Subramani, Dhatchayini [1 ]
Alahari, Suresh K. [1 ]
机构：
[1] LSU Sch Med, Stanley S Scott Canc Ctr, Dept Biochem, New Orleans, LA 70112 USA
来源：
MOLECULAR CANCER | 2010年 / 9卷
关键词：
CELL-ADHESION RECEPTORS; SIGNAL-TRANSDUCTION; ALPHA-5-BETA-1; INTEGRIN; EXPRESSION; PROTEIN; GROWTH; OVARIAN; TRAFFICKING; MIGRATION; GENE;
D O I：
10.1186/1476-4598-9-312
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: Ras, Rho, Rab, Ran, and Arf. Rab family proteins are important in regulating signal transduction and cellular processes such as differentiation, proliferation, vesicle transport, nuclear assembly, and cytoskeleton formation. However, some Rab proteins have been reported to be necessary for the adhesion and migration of cancer cells. Although Ras and Rho family members have been strongly implicated in cancer progression, knowledge of Rabs action in this regard is limited. Some reports have also linked Rab GTPases with cancer cell migration and invasiveness. This review discusses the implications of the involvement of Rabs in malignant transformation and cancer therapy through integrin-mediated signaling events, with particular emphasis on breast cancer.
引用
收藏
页数：9
相关论文
共 66 条
  • [1] The Emerging Role of the RAB25 Small GTPase in Cancer
    Agarwal, Roshan
    Jurisica, Igor
    Mills, Gordon B.
    Cheng, Kwai Wa
    [J]. TRAFFIC, 2009, 10 (11) : 1561 - 1568
  • [2] Alahari SK, 2002, INT REV CYTOL, V220, P145
  • [3] Aplin AE, 1998, PHARMACOL REV, V50, P197
  • [4] Rab GTPase function in Golgi trafficking
    Barr, Francis A.
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2009, 20 (07) : 780 - 783
  • [5] Role of Rab9 GTPase in facilitating receptor recruitment by TIP47
    Carroll, KS
    Hanna, J
    Simon, I
    Krise, J
    Barbero, P
    Pfeffer, SR
    [J]. SCIENCE, 2001, 292 (5520) : 1373 - 1376
  • [6] Cary Leslie A., 1999, Frontiers in Bioscience, V4, pD102, DOI 10.2741/Cary
  • [7] Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
    Caswell, Patrick T.
    Chan, May
    Lindsay, Andrew J.
    McCaffrey, Mary W.
    Boettiger, David
    Norman, Jim C.
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 183 (01) : 143 - 155
  • [8] Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments
    Caswell, Patrick T.
    Spence, Heather J.
    Parsons, Maddy
    White, Dominic P.
    Clark, Katherine
    Cheng, Kwai Wa
    Mills, Gordon B.
    Humphries, Martin J.
    Messent, Anthea J.
    Anderson, Kurt I.
    McCaffrey, Mary W.
    Ozanne, Bradford W.
    Norman, Jim C.
    [J]. DEVELOPMENTAL CELL, 2007, 13 (04) : 496 - 510
  • [9] Ceresa BP, 2006, HISTOL HISTOPATHOL, V21, P987, DOI 10.14670/HH-21.987
  • [10] Loss of RAB25 expression in breast cancer
    Cheng, Ji-Ming
    Ding, Ming
    Aribi, Ahmed
    Shah, Prabodh
    Rao, Krishna
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (12) : 2957 - 2964
1234567