Effects of Topical Brinzolamide/Timolol on Refractive Outcomes in Eyes with Myopic Regression after Corneal Refractive Surgeries

被引:0
作者
Park, Young Min [1 ]
Hwang, Sang Ho [2 ]
Lee, Ji Woong [3 ,4 ]
Lee, Jong Soo [3 ,4 ]
机构
[1] Gyeongsang Natl Univ, Changwon Hosp, Sch Med, Dept Ophthalmol, 11 Samjeongja Ro, Changwon Si 51472, Gyeongsangnam D, South Korea
[2] Junggeun Eye Clin, Pusan, South Korea
[3] Pusan Natl Univ, Sch Med, Dept Ophthalmol, 1-10 Ami Dong, Pusan 602739, South Korea
[4] Pusan Natl Univ Hosp, Med Res Inst, 1-10 Ami Dong, Pusan 602739, South Korea
关键词
Brinzolamide/timolol; LASEK; LASIK; myopic regression; IN-SITU KERATOMILEUSIS; ANTERIOR-CHAMBER DEPTH; OPEN-ANGLE GLAUCOMA; 1-PERCENT/TIMOLOL; 0.5-PERCENT; OCULAR HYPERTENSION; FIXED COMBINATION; PRESSURE; EFFICACY; TIMOLOL; REDUCTION;
D O I
10.3923/ijp.2016.556.561
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background and Objectives: To investigate the effects of topical brinzolamide/timolol on the inhibition of myopic regression after laser in situ keratomileusis (LASIK) and laser-assisted subepithelial keratomileusis (LASEK). Methodology: Sixty six eyes of 66 patients with myopic regression after corneal refractive surgery were classified into two groups: LASIK and LASEK group. All patients received topical brinzolamide/timolol twice a day for 2 months since the mean postoperative 6 months. Patients had complete eye examinations including Uncorrected Distance Visual Acuities (UDVA), intraocular pressure (IOP), anterior chamber angle and depth measurement, Spherical Equivalent (SE) and astigmatism with K value. Results: The value of IOP, SE and K at 1 and 2 months after the brinzolamide/timolol treatment were significantly reduced compared to the initial examination. The initial UDVA at 1 and 2 months after the treatment was markedly improved on the both groups. The angle and depth of anterior chamber were significantly changed for 2 months, although IOP, K value and SE reduction of both groups after the treatment for 2 months was markedly reduced. There was no significant difference in the effects of brinzolamide/timolol treatment between LASIK and LASEK group. Conclusion: Corneal biomechanical strength related factors including IOP, anterior chamber angle and depth are thought to be more responsible for the myopic regression. The improvement of myopic regression with brinzolamide/timolol treatment might be a result of the backward movement of the cornea and flattening of its curvature, which is presumably restricted to early treatment periods within 1 year.
引用
收藏
页码:556 / 561
页数:6
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