Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and lsogenic β-Lactam-Resistant Mutants

被引：60

作者：

Fraile-Ribot, Pablo A. ^{[1
]}

Zamorano, Laura ^{[1
]}

Orellana, Rocio ^{[1
]}

del Barrio-Tofino, Ester ^{[1
]}

Sanchez-Diener, Irina ^{[1
]}

Cortes-Lara, Sara ^{[1
]}

Lopez-Causape, Carla ^{[1
]}

Cabot, Gabriel ^{[1
]}

Bou, German ^{[2
]}

Martinez-Martinez, Luis ^{[3
]}

Oliver, Antonio ^{[1
]}

Galan, Fatima

Gracia, Irene

Antonio Rodriguez, Manuel

Martin, Lina

Manuel Sanchez, Juan

Vinuela, Laura

Victoria Garcia, Ma

Antonio Lepe, Jose

Aznar, Javier

Lopez-Hernandez, Inma

Seral, Cristina

Javier Castillo-Garcia, Francisco

Isabel Lopez-Calleja, Ana

Aspiroz, Carmen

de la Iglesia, Pedro

Ramon, Susana

Riera, Elena

Cruz Perez, Maria

Gallegos, Carmen

Calvo, Jorge

Dolores Quesada, Maria

Marco, Francesc

Hoyos, Yannick

Pablo Horcajada, Juan

Larrosa, Nieves

Jose Gonzalez, Juan

Tubau, Fe

Capilla, Silvia

Olga Perez-Moreno, Mar

Jose Centelles, Ma

Padilla, Emma

Rivera, Alba

Mirelis, Beatriz

Elisa Rodriguez-Tarazona, Raquel

Arenal-Andres, Noelia

del Pilar Ortega, Maria

Megias, Gregoria

Garcia, Inmaculada

Colmenarejo, Cristina

机构：

[1] Inst Invest Sanitaria IIles Balears IdISBa, Serv Microbiol, Hosp Son Espases, Palma De Mallorca, Spain

[2] Inst Invest Biomed A Coruna INIBIC, Hosp Univ La Coruna, Serv Microbiol, La Coruna, Spain

[3] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Gest Clin Microbiol, Hosp Reina Sofia,Dept Microbiol, Cordoba, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 02期

关键词：

Pseudomonas aeruginosa; imipenem-relebactam; whole-genome sequencing; multidrug resistance; extensively drug resistant; beta-lactam resistance mechanisms; antibiotic resistance; AVIBACTAM;

D O I：

10.1128/AAC.02165-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Imipenem and imipenem-relebactam MICs were determined for 1,445 Pseudomonas aeruginosa clinical isolates and a large panel of isogenic mutants showing the most relevant mutation-driven beta-lactam resistance mechanisms. Imipenem-relebactam showed the highest susceptibility rate (97.3%), followed by colistin and ceftolozane-tazobactam (both 94.6%). Imipenem-relebactam MICs remained <= 2 mu g/ml in all 16 isogenic PAO1 mutants and in 8 pairs of extensively drug-resistant clinical strains that had developed resistance to ceftolozane-tazobactam and ceftazidime-avibactam due to mutations in OXA-10 or AmpC.

引用

页数：6

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