A New CDK9 Inhibitor on the Block to Treat Hematologic Malignancies

被引：10

作者：

Alcon, Clara ^{[1
]}

Manzano-Munoz, Albert ^{[1
]}

Montero, Joan ^{[1
]}

机构：

[1] BIST, Inst Bioengn Catalonia IBEC, Barcelona, Spain

来源：

CLINICAL CANCER RESEARCH | 2020年 / 26卷 / 04期

关键词：

TARGET;

D O I：

10.1158/1078-0432.CCR-19-3670

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CDK9-specific inhibition with AZD4573 impairs cancer-promoting gene expression such as MCL-1 and has been proven effective in hematologic malignancies preclinical models. This new clinical candidate should be further explored in the clinic not only as a monotherapy but also in combination with BH3 mimetics to prevent treatment resistance.

引用

页码：761 / 763

页数：3

共 6 条

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