Successful growth of fresh retinoblastoma cells in chorioallantoic membrane

被引：3

作者：

Fialho, Silvia L. ^{[1
]}

Silvestrini, Barbara R. ^{[1
]}

Vieira, Juliana ^{[2
]}

Paiva, Mayara R. B. ^{[1
]}

Silva, Luciana M. ^{[3
]}

Chahud, Fernando ^{[4
]}

Silva-Cunha, Armando ^{[5
]}

Correa, Zelia M. ^{[6
,7
]}

Jorge, Rodrigo ^{[2
]}

机构：

[1] Ezequiel Dias Fdn, Pharmaceut Res & Dev, Belo Horizonte, MG, Brazil

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Ophthalmol, Ribeirao Preto, Brazil

[3] Ezequiel Dias Fdn, Dept Cell Biol, Belo Horizonte, MG, Brazil

[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, Ribeirao Preto, Brazil

[5] Univ Fed Minas Gerais, Sch Pharm, Belo Horizonte, MG, Brazil

[6] Wilmer Eye Inst, Dept Ophthalmol, Johns Hopkins Med, Baltimore, MD 21287 USA

[7] Univ Cincinnati, Coll Med, Dept Ophthalmol, Cincinnati, OH USA

来源：

INTERNATIONAL JOURNAL OF RETINA AND VITREOUS | 2020年 / 6卷 / 01期

关键词：

Retinoblastoma; Tumor models; Chorioallantoic membrane; CAM assay; CHICK-EMBRYO;

D O I：

10.1186/s40942-020-00236-x

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease.

引用

页数：4

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