Multicenter Epidemiologic Study of Coronavirus Disease-Associated Mucormycosis, India

被引：320

作者：

Patel, Atul ^{[1
]}

Agarwal, Ritesh ^{[2
]}

Rudramurthy, Shivaprakash M. ^{[2
]}

Shevkani, Manoj ^{[3
]}

Xess, Immaculata ^{[4
]}

Sharma, Ratna ^{[5
]}

Savio, Jayanthi ^{[6
]}

Sethuraman, Nandini ^{[7
]}

Madan, Surabhi ^{[8
]}

Shastri, Prakash ^{[9
]}

Thangaraju, Deepak ^{[10
]}

Marak, Rungmei ^{[11
]}

Tadepalli, Karuna ^{[12
]}

Savaj, Pratik ^{[13
]}

Sunavala, Ayesha ^{[14
]}

Gupta, Neha ^{[15
]}

Singhal, Tanu ^{[16
]}

Muthu, Valliappan ^{[2
]}

Chakrabarti, Arunaloke ^{[2
]}

机构：

[1] Sterling Hosp, Ahmadabad, Gujarat, India

[2] Postgrad Inst Med Educ & Res, Chandigarh, India

[3] Avaron Hosp, Ahmadabad, Gujarat, India

[4] All India Inst Med Sci, New Delhi, India

[5] Apollo Hosp, Hyderabad, India

[6] St Johns Med Coll, Bengaluru, India

[7] Apollo Hosp, Chennai, Tamil Nadu, India

[8] Care Inst Med Sci, Ahmadabad, Gujarat, India

[9] Sir Ganga Ram Hosp, New Delhi, India

[10] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India

[11] Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India

[12] All India Inst Med Sci, Bhopal, India

[13] Venus Hosp, Surat, India

[14] Hinduja Hosp, Mumbai, Maharashtra, India

[15] Medanta Med, Gurgaon, India

[16] Kokilaben Hosp, Mumbai, Maharashtra, India

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 09期

关键词：

CARE;

D O I：

10.3201/eid2709.210934

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During September-December 2020, we conducted a multi-center retrospective study across India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID-19)-associated mucormycosis (CAM). Among 287 mucormycosis patients, 187 (65.2%) had CAM; CAM prevalence was 0.27% among hospitalized COVID-19 patients. We noted a 2.1-fold rise in mucormycosis during the study period compared with September-December 2019. Uncontrolled diabetes mellitus was the most common underlying disease among CAM and non-CAM patients. COVID-19 was the only underlying disease in 32.6% of CAM patients. COVID-19-related hypoxemia and improper glucocorticoid use independently were associated with CAM. The mucormycosis case-fatality rate at 12 weeks was 45.7% but was similar for CAM and non-CAM patients. Age, rhino-orbital-cerebral involvement, and intensive care unit admission were associated with increased mortality rates; sequential antifungal drug treatment improved mucormycosis survival. The COVID-19 pandemic has led to increases in mucormycosis in India, partly from inappropriate glucocorticoid use.

引用

页码：2349 / 2359

页数：11

共 29 条

[1] Can COVID-19 cause diabetes? [J].

Accili, Domenico .

NATURE METABOLISM, 2021, 3 (02) :123-125

[2] The double-edged sword of systemic corticosteroid therapy in viral pneumonia: A case report and comparative review of influenza-associated mucormycosis versus COVID-19 associated mucormycosis [J].

Ahmadikia, Kazem ;

Hashemi, Seyed Jamal ;

Khodavaisy, Sadegh ;

Getso, Muhammad Ibrahim ;

Alijani, Neda ;

Badali, Hamid ;

Mirhendi, Hossein ;

Salehi, Mohammadreza ;

Tabari, Azin ;

Mohammadi Ardehali, Mojtaba ;

Kord, Mohammad ;

Roilides, Emmanuel ;

Rezaie, Sassan .

MYCOSES, 2021, 64 (08) :798-808

[3] Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? [J].

Antinori, Spinello ;

Bonazzetti, Cecilia ;

Gubertini, Guido ;

Capetti, Amedeo ;

Pagani, Cristina ;

Morena, Valentina ;

Rimoldi, Sara ;

Galimberti, Laura ;

Sarzi-Puttini, Piercarlo ;

Ridolfo, Anna Lisa .

AUTOIMMUNITY REVIEWS, 2020, 19 (07)

[4] Clinical characteristics and risk factors for the isolation of multi-drug-resistant Gram-negative bacteria from critically ill patients with COVID-19 [J].

Baiou, A. ;

Elbuzidi, A. A. ;

Bakdach, D. ;

Zaqout, A. ;

Alarbi, K. M. ;

Bintaher, A. A. ;

Ali, M. M. B. ;

Elarabi, A. M. ;

Ali, G. A. M. ;

Daghfal, J. ;

Almaslamani, M. A. ;

Ibrahim, A. S. S. ;

Alkhal, A. ;

Omrani, A. S. .

JOURNAL OF HOSPITAL INFECTION, 2021, 110 :165-171

[5] State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia [J].

Chong, Woon H. ;

Saha, Biplab K. ;

Ramani, Ananthakrishnan ;

Chopra, Amit .

INFECTION, 2021, 49 (04) :591-605

[6] Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium [J].

Cornely, Oliver A. ;

Alastruey-Izquierdo, Ana ;

Arenz, Dorothee ;

Chen, Sharon C. A. ;

Dannaoui, Eric ;

Hochhegger, Bruno ;

Hoenigl, Martin ;

Jensen, Henrik E. ;

Lagrou, Katrien ;

Lewis, Russell E. ;

Mellinghoff, Sibylle C. ;

Mer, Mervyn ;

Pana, Zoi D. ;

Seidel, Danila ;

Sheppard, Donald C. ;

Wahba, Roger ;

Akova, Murat ;

Alanio, Alexandre ;

Al-Hatmi, Abdullah M. S. ;

Arikan-Akdagli, Sevtap ;

Badali, Hamid ;

Ben-Ami, Ronen ;

Bonifaz, Alexandro ;

Bretagne, Stephane ;

Castagnola, Elio ;

Chayakulkeeree, Methee ;

Colombo, Arnaldo L. ;

Corzo-Leon, Dora E. ;

Drgona, Lubos ;

Groll, Andreas H. ;

Guinea, Jesus ;

Heussel, Claus-Peter ;

Ibrahim, Ashraf S. ;

Kanj, Souha S. ;

Klimko, Nikolay ;

Lackner, Michaela ;

Lamoth, Frederic ;

Lanternier, Fanny ;

Lass-Floerl, Cornelia ;

Lee, Dong-Gun ;

Lehrnbecher, Thomas ;

Lmimouni, Badre E. ;

Mares, Mihai ;

Maschmeyer, Georg ;

Meis, Jacques F. ;

Meletiadis, Joseph ;

Morrissey, C. Orla ;

Nucci, Marcio ;

Oladele, Rita ;

Pagano, Livio .

LANCET INFECTIOUS DISEASES, 2019, 19 (12) :E405-E421

[7] Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection [J].

Files, Jacob K. ;

Boppana, Sushma ;

Perez, Mildred D. ;

Sarkar, Sanghita ;

Lowman, Kelsey E. ;

Qin, Kai ;

Sterrett, Sarah ;

Carlin, Eric ;

Bansal, Anju ;

Sabbaj, Steffanie ;

Long, Dustin M. ;

Kutsch, Olaf ;

Kobie, James ;

Goepfert, Paul A. ;

Erdmann, Nathan .

JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (01)

[8] Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature [J].

Garg, Deepak ;

Muthu, Valliappan ;

Sehgal, Inderpaul Singh ;

Ramachandran, Raja ;

Kaur, Harsimran ;

Bhalla, Ashish ;

Puri, Goverdhan D. ;

Chakrabarti, Arunaloke ;

Agarwal, Ritesh .

MYCOPATHOLOGIA, 2021, 186 (02) :289-298

[9] Innate and Adaptive Immunity to Mucorales [J].

Ghuman, Harlene ;

Voelz, Kerstin .

JOURNAL OF FUNGI, 2017, 3 (03)

[10] The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports [J].

Jeong, W. ;

Keighley, C. ;

Wolfe, R. ;

Lee, W. L. ;

Slavin, M. A. ;

Kong, D. C. M. ;

Chen, S. C. -A. .

CLINICAL MICROBIOLOGY AND INFECTION, 2019, 25 (01) :26-34

← 1 2 3 →