Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

被引：36

作者：

Cannioto, Rikki ^{[1
]}

LaMonte, Michael J. ^{[2
]}

Risch, Harvey A. ^{[3
]}

Hong, Chi-Chen ^{[1
]}

Sucheston-Campbell, Lara E. ^{[1
]}

Eng, Kevin H. ^{[4
]}

Szender, J. Brian ^{[5
]}

Chang-Claude, Jenny ^{[6
,7
]}

Schmalfeldt, Barbara ^{[8
]}

Klapdor, Ruediger ^{[9
]}

Gower, Emily ^{[1
,2
]}

Minlikeeva, Albina N. ^{[1
,2
]}

Zirpoli, Gary R. ^{[1
]}

Bandera, Elisa V. ^{[10
]}

Berchuck, Andrew ^{[11
]}

Cramer, Daniel ^{[12
,13
]}

Doherty, Jennifer A. ^{[14
]}

Edwards, Robert P. ^{[15
,16
,17
]}

Fridley, Brooke L. ^{[18
]}

Goode, Ellen L. ^{[19
]}

Goodman, Marc T. ^{[20
]}

Hogdall, Estrid ^{[21
,22
]}

Hosono, Satoyo ^{[23
]}

Jensen, Allan ^{[21
]}

Jordan, Susan ^{[24
,25
]}

Kjaer, Susanne K. ^{[21
,26
]}

Matsuo, Keitaro ^{[27
]}

Ness, Roberta B. ^{[28
]}

Olsen, Catherine M. ^{[25
]}

Olson, Sara H. ^{[29
]}

Pearce, Celeste Leigh ^{[30
]}

Pike, Malcolm C. ^{[29
]}

Rossing, Mary Anne ^{[31
]}

Szamreta, Elizabeth A. ^{[10
]}

Thompson, Pamela J. ^{[20
]}

Tseng, Chiu-Chen ^{[32
]}

Vierkant, Robert A. ^{[33
]}

Webb, Penelope M. ^{[25
]}

Wentzensen, Nicolas ^{[34
]}

Wicklund, Kristine G. ^{[31
]}

Winham, Stacey J. ^{[33
]}

Wu, Anna H. ^{[32
]}

Modugno, Francesmary ^{[15
,16
,17
,35
]}

Schildkraut, Joellen M. ^{[36
]}

Terry, Kathryn L. ^{[12
,13
]}

Kelemen, Linda E. ^{[37
]}

Moysich, Kirsten B. ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA

[2] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Buffalo, NY USA

[3] Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA

[4] Roswell Pk Canc Inst, Dept Biostat & Bioinformat, Buffalo, NY 14263 USA

[5] Roswell Pk Canc Inst, Dept Gynecol Oncol, Buffalo, NY 14263 USA

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] Univ Med Ctr Hamburg Eppendorf, UCCH, Hamburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf UKE, Dept Gynecol, Hamburg, Germany

[9] Hannover Med Sch, Dept Obstet & Gynecol, Hannover, Niedersachsen, Germany

[10] Rutgers Canc Inst New Jersey, Canc Prevent & Control, New Brunswick, NJ USA

[11] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA

[12] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 75 Francis St, Boston, MA 02115 USA

[13] Harvard Med Sch, Boston, MA USA

[14] Geisel Sch Med Dartmouth Med, Dept Epidemiol, Hanover, NH USA

[15] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA

[16] Magee Womens Res Inst, Womens Canc Res Program, Ovarian Canc Ctr Excellence, Pittsburgh, PA USA

[17] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA

[18] Univ Kansas, Med Ctr, Biostat & Informat Shared Resource, Kansas City, KS 66103 USA

[19] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[20] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, Los Angeles, CA 90048 USA

[21] Danish Canc Soc, Res Ctr, Dept Virus Lifestyle & Genes, Copenhagen, Denmark

[22] Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Copenhagen, Denmark

[23] Aichi Canc Ctr, Div Epidemiol & Prevent, Res Inst, Nagoya, Aichi, Japan

[24] Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

[25] QIMR Berghofer Med Res Inst, Populat Hlth Dept, Brisbane, Qld, Australia

[26] Univ Copenhagen, Rigshosp, Dept Gynaecol, Copenhagen, Denmark

[27] Aichi Canc Ctr, Div Mol Med, Res Inst, Nagoya, Aichi, Japan

[28] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[29] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[30] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[31] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA

[32] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[33] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA

[34] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[35] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA

[36] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[37] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2016年 / 25卷 / 07期

基金：

英国医学研究理事会;

关键词：

POOLED ANALYSIS; SINGLE-ITEM; SEDENTARY BEHAVIOR; HORMONE-THERAPY; INFLAMMATION; MARKERS; OBESITY; CONSUMPTION; ADIPOKINES; EXERCISE;

D O I：

10.1158/1055-9965.EPI-15-1330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease. (C) 2016 AACR.

引用

页码：1114 / 1124

页数：11

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