A common 8q24 variant and the risk of colon cancer: A population-based case-control study

被引：39

作者：

Li, Li ^{[1
,2
,4
]}

Plummer, Sarah J. ^{[5
]}

Thompson, Cheryl L. ^{[1
,2
,4
]}

Merkulova, Alona ^{[5
]}

Acheson, Louise S. ^{[1
,3
]}

Tucker, Thomas C. ^{[6
]}

Casey, Graham ^{[4
,5
]}

机构：

[1] Case Western Reserve Univ, Dept Family Med, Div Res, Univ Hosp Cleveland, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Univ Hosp Cleveland, Dept Reprod Biol, Cleveland, OH 44106 USA

[4] Case Comprehens Canc Ctr, Case Ctr Transdisciplinary Res Energet & Canc, Cleveland, OH USA

[5] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44106 USA

[6] Univ Kentucky, Canc Control Program, Lexington, KY USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2008年 / 17卷 / 02期

关键词：

D O I：

10.1158/1055-9965.EPI-07-0713

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three recent studies identified common variants on 8q24 that confer modestly increased susceptibility to colorectal cancer. Here, we replicate the association in a population-based case-control study of colon cancer, including 561 cases and 721 unrelated controls. The rs6983267 marker was significantly associated with colon cancer risk. Compared with those homozygous for the T allele, the heterozygous and homozygous carriers for the G allele had an age-adjusted odds ratio of 1.39 (95% confidence interval, 1.03-1.88) and 1.68 (95% confidence interval, 1.21-2.33), respectively. An additive model showed strong evidence for a gene-dose response relationship (P-trend = 0.0022). The association remained statistically significant when restricted to Caucasians only (527 cases and 679 controls; P-trend = 0.0056). Further adjustment for other known risk factors did not alter the results. Stratified analysis revealed no evidence for effect modification by family history of colorectal cancer, age, or gender. These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer.

引用

页码：339 / 342

页数：4

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