Characterization of Garvicin ML, a Novel Circular Bacteriocin Produced by Lactococcus garvieae DCC43, Isolated from Mallard Ducks (Anas platyrhynchos)

被引：92

作者：

Borrero, Juan ^{[1
]}

Brede, Dag A. ^{[2
]}

Skaugen, Morten ^{[2
]}

Diep, Dzung B. ^{[2
]}

Herranz, Carmen ^{[1
]}

Nes, Ingolf F. ^{[2
]}

Cintas, Luis M. ^{[1
]}

Hernandez, Pablo E. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Vet, Dept Nutr Bromatol & Tecnol Alimentos, E-28040 Madrid, Spain

[2] Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, Lab Microbial Gene Technol, N-1432 As, Norway

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 01期

关键词：

LACTIC-ACID BACTERIA; ANTIMICROBIAL PEPTIDES; ANTIBIOTIC AS-48; SAFETY ASPECTS; STREPTOCOCCUS; PREDICTION; PROTEINS; IDENTIFICATION; CARNOCYCLIN; GASSERICIN;

D O I：

10.1128/AEM.01173-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lactococcus garvieae DCC43 produces a bacteriocin, garvicin ML (GarML), with a molecular mass of 6,004.2 Da. Data from de novo amino acid sequencing by tandem mass spectrometry and nucleotide sequencing by reverse genetics suggested that the bacteriocin is synthesized as a 63-amino-acid precursor with a 3-amino-acid leader peptide that is removed by cleavage. Subsequently, a covalent linkage between the N and C termini forms the mature version of this novel 60-amino-acid circular bacteriocin.

引用

页码：369 / 373

页数：5

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