Synthesis and application of new chiral ligands for the asymmetric borane reduction of prochiral ketones

被引：56

作者：

Hulst, R

Heres, H

Peper, NCMW

Kellogg, RM

机构：

[1] Dept. Organ. and Molec. Inorg. Chem., Groningen Ctr. Catalys. Synthesis, University of Groningen, 9747 AG, Groningen

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 05期

关键词：

D O I：

10.1016/0957-4166(96)00154-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two chiral nonracemic gamma-amino alcohols, ephedrine thiol and the corresponding (thio)-phosphoramidates and (thio)-phosphinamides have been examined as catalysts for the reduction of propiophenone by various boranes. Up to 95% e.e. can be obtained with the phosphorus derivatives. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1373 / 1384

页数：12

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