Natural killer cell neoplasm: biology and pathology

被引：19

作者：

Ham, Maria Francisca ^{[2
]}

Ko, Young-Hyeh ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Pathol, Samsung Med Ctr, Seoul 135710, South Korea

[2] Univ Indonesia, Dept Anat Pathol, Cipto Mangunkusumo Natl Cent Gen Hosp, Jakarta, Indonesia

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2010年 / 92卷 / 05期

关键词：

NK; Cell; Lymphoma; Biology; Pathology; EPSTEIN-BARR-VIRUS; GRANULAR LYMPHOCYTE LEUKEMIA; CATENIN GENE-MUTATIONS; IN-SITU HYBRIDIZATION; NK CELLS; NASAL-TYPE; C-KIT; T-CELL; LYMPHOPROLIFERATIVE DISEASE; RECEPTOR EXPRESSION;

D O I：

10.1007/s12185-010-0738-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Natural killer (NK) cell neoplasm is a heterogeneous disease group. In the latest World Health Organization (WHO) classification of tumours of hematopoietic and lymphoid tissues (2008), disease entities considered as NK-cell derivation include NK-lymphoblastic leukemia/lymphoma, chronic lymphoproliferative disorders of NK cells, aggressive NK-cell leukemia, and extranodal NK-cell lymphoma, nasal-type. Despite recent advances in NK-cell research, which have expanded our understanding of the biology of NK-cell neoplasm, it cannot yet be sharply delineated from myeloid neoplasms and T-cell neoplasms even in some "well-known" entity, such as extranodal NK/T-cell lymphoma. This review describes current knowledge of the biology of NK cells and pathology of NK neoplasms as classified in the 2008 WHO classification of tumours of hematopoietic and lymphoid tissues.

引用

页码：681 / 689

页数：9

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