The effect of peroxynitrite and some antioxidants on the rate of osmotic hemolysis of bovine erythrocytes

被引：0
|
作者：
Wróbel, A
Lukaszynska, B
Kedzierska, J
机构：
[1] Wroclaw Tech Univ, Inst Phys, PL-50370 Wroclaw, Poland
[2] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland
来源：
CELLULAR & MOLECULAR BIOLOGY LETTERS | 2003年 / 8卷 / 02期
关键词：
peroxynitrite; erythrocyte; hemolysis; antioxidant; stopped-flow technique;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bovine erythrocytes treated with peroxynitrite (ONOO-), a cytotoxic species formed in vivo via the reaction of nitric oxide (NO.) and the superoxide anion (O-2(-.)), show an increased rate of hemolysis on sudden osmotic stress. The increase in the rate was peroxynitrite concentration dependent. In the presence of some antioxidants (uric acid, ascorbic acid, glutathione, melatonin and albumin), this effect was significantly lower, with ascorbic acid as the most efficient antioxidant.
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页码：455 / 460
页数：6
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