Mammalian legumain - A lysosomal cysteine protease with extracellular functions?

被引：23

作者：

Ngoc Nguyen Lunde ^{[1
]}

Bosnjak, Tatjana ^{[1
]}

Solberg, Rigmor ^{[1
]}

Johansen, Harald Thidemann ^{[1
]}

机构：

[1] Univ Oslo, Dept Pharm, Sect Pharmacol & Pharmaceut Biosci, Oslo, Norway

来源：

BIOCHIMIE | 2019年 / 166卷

关键词：

AEP; Biomarker; Cysteine protease; Extracellular function; Legumain; ATHEROSCLEROTIC PLAQUE; SECRETED PROTEINS; CYSTATIN E/M; ENDOPEPTIDASE; ACTIVATION; DIFFERENTIATION; BONE; DEGRADATION; CATHEPSINS; CELLS;

D O I：

10.1016/j.biochi.2019.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cysteine protease legumain (asparaginyl endopeptidase, AEP) plays important roles in normal physiology but is also associated with several disorders, such as atherosclerosis, osteoporosis, cancer and neurodegenerative diseases. The functional roles of legumain have mainly been associated with the presence in lysosomes where legumain is active and mediates processing of multiple proteins, such as the conversion of single to double chain forms of cysteine cathepsins. However, in recent years, a number of studies point to extracellular roles of legumain in addition to the pivotal roles in the lysosomes. In this review, recent knowledge on novel extracellular functions of this protease will be addressed and new discoveries in relation to the diseases mentioned above will be presented. (C) 2019 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：77 / 83

页数：7

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