Peripartum and neonatal outcomes of small- for- gestational- age infants with gastroschisis

被引:13
作者
Girsen, Anna I. [1 ]
Do, Samantha [1 ]
Davis, Alexis S. [3 ,6 ]
Hintz, Susan R. [2 ,6 ]
Desai, Arti K. [4 ]
Mansour, Trina [4 ]
Merritt, T. Allen [5 ]
Oshiro, Bryan T. [4 ]
El-Sayed, Yasser Y. [1 ,6 ]
Blumenfeld, Yair J. [1 ,6 ]
机构
[1] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Pediat, Div Neonatal & Dev Med, Stanford, CA 94305 USA
[3] Pediatrix Med Grp, San Jose, CA USA
[4] Loma Linda Univ, Sch Med, Dept Obstet & Gynecol, Loma Linda, CA USA
[5] Loma Linda Univ, Sch Med, Dept Pediat, Div Neonatol, Loma Linda, CA USA
[6] Lucile Packard Childrens Hosp Stanford, Fetal & Pregnancy Hlth Program, Palo Alto, CA USA
关键词
ABDOMINAL-WALL DEFECTS; FETAL WEIGHT; BIRTH-WEIGHT; GROWTH; FETUSES; DIAGNOSIS; FORMULAS; BODY; TERM;
D O I
10.1002/pd.4562
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
ObjectivesNeonates with gastroschisis are often small for gestational age (SGA) based on population nomograms. Our objective was to evaluate the effect of SGA on perinatal and neonatal outcomes in cases of gastroschisis. MethodsThis is a retrospective study of neonates with prenatally diagnosed gastroschisis from two academic centers between 2008 and 13. Perinatal and neonatal outcomes of neonates with SGA at birth were compared with appropriate-for-gestational-age (AGA) neonates. The primary composite outcome was defined as any of the following: neonatal sepsis, short bowel syndrome at discharge, prolonged mechanical ventilation (upper quartile for the cohort), bowel atresia or death. ResultsWe identified 112 cases of gastroschisis, 25 of whom (22%) were SGA at birth. There were no differences in adverse peripartum outcomes between SGA and AGA infants. No difference was found in the primary composite neonatal outcome (52% vs 36%, p=0.21), but SGA infants were more likely to have prolonged mechanical ventilation (44% vs 22%, p=0.04) and prolonged length of stay (LOS) (52% vs 22%, p=0.007). After adjusting for GA at delivery, SGA remained associated with prolonged LOS (OR=4.3, CI: 1.6-11.8). ConclusionAmong infants with gastroschisis, SGA at birth is associated with a fourfold increase in odds for prolonged LOS, independent of GA. (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码:477 / 482
页数:6
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