Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan

被引：21

作者：

Azuma, Takashi ^{[1
]}

Ishiuchi, Hirotaka ^{[1
]}

Inoyama, Tomomi ^{[1
]}

Teranishi, Yusuke ^{[1
]}

Yamaoka, Misato ^{[1
]}

Sato, Takaji ^{[1
]}

Yamashita, Naoyuki ^{[2
]}

Tanaka, Hiroaki ^{[2
]}

Mino, Yoshiki ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka, Japan

[2] Kyoto Univ, Res Ctr Environm Qual Management, Otsu, Shiga, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 06期

关键词：

INFLUENZA-A H1N1; WASTE-WATER; OSELTAMIVIR CARBOXYLATE; NEURAMINIDASE INHIBITOR; SEASONAL INFLUENZA; ENVIRONMENTAL FATE; ANTIVIRAL DRUGS; SURFACE WATERS; PHARMACEUTICALS; REMOVAL;

D O I：

10.1371/journal.pone.0131412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This is the first report of the detection of two new anti-influenza drugs, peramivir (PER) and laninamivir (LAN), in Japanese sewage effluent and river waters. Over about 1 year from October 2013 to July 2014, including the influenza prevalence season in January and February 2014, we monitored for five anti-influenza drugs-oseltamivir (OS), oseltamivir carboxylate (OC), zanamivir (ZAN), PER, and LAN-in river waters and in sewage effluent flowing into urban rivers of the Yodo River system in Japan. The dynamic profiles of these anti-influenza drugs were synchronized well with that of the numbers of influenza patients treated with the drugs. The highest levels in sewage effluents and river waters were, respectively, 82 and 41 ng/L (OS), 347 and 125 ng/L (OC), 110 and 35 ng/L (ZAN), 64 and 11 ng/L (PER), and 21 and 9 ng/L (LAN). However, application of ozone treatment before discharge from sewage treatment plants was effective in reducing the levels of these anti-influenza drugs in effluent. The effectiveness of the ozone treatment and the drug dependent difference in susceptibility against ozone were further evidenced by ozonation of a STP effluent in a batch reactor. These findings should help to promote further environmental risk assessment of the generation of drug-resistant influenza viruses in aquatic environments.

引用

页数：11

共 62 条

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