4'-C-nucleoside derivatives: Synthesis and antiviral properties

被引：5

作者：

Alexandrova, L. A. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

hepatitis C virus; HCV NTPase/helicase; HCV RNA-dependent RNA polymerase; 4 '-C-modified nucleosides; nucleosides; nucleoside 5 '-O-triphosphates; pyrimidine nucleosides; HEPATITIS-C VIRUS; PHOSPHORAMIDATE PROTIDE TECHNOLOGY; HALO SUGAR NUCLEOSIDES; ANTI-HIV ACTIVITY; 4'-SUBSTITUTED NUCLEOSIDES; 2,3-DIDEHYDRO-2,3-DIDEOXYADENOSINE D4A; 4-SUBSTITUTED NUCLEOSIDES; POTENT INHIBITOR; REPLICATION; 4'-AZIDOCYTIDINE;

D O I：

10.1134/S1068162011060021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of 4'-C-modified nucleosides and their derivatives, as well as the structure-activity relationship toward hepatitis C virus were discussed.

引用

页码：651 / 671

页数：21

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