4'-C-nucleoside derivatives: Synthesis and antiviral properties

被引：5
|
作者：
Alexandrova, L. A. [1 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
hepatitis C virus; HCV NTPase/helicase; HCV RNA-dependent RNA polymerase; 4 '-C-modified nucleosides; nucleosides; nucleoside 5 '-O-triphosphates; pyrimidine nucleosides; HEPATITIS-C VIRUS; PHOSPHORAMIDATE PROTIDE TECHNOLOGY; HALO SUGAR NUCLEOSIDES; ANTI-HIV ACTIVITY; 4'-SUBSTITUTED NUCLEOSIDES; 2,3-DIDEHYDRO-2,3-DIDEOXYADENOSINE D4A; 4-SUBSTITUTED NUCLEOSIDES; POTENT INHIBITOR; REPLICATION; 4'-AZIDOCYTIDINE;
D O I：
10.1134/S1068162011060021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of 4'-C-modified nucleosides and their derivatives, as well as the structure-activity relationship toward hepatitis C virus were discussed.
引用
收藏
页码：651 / 671
页数：21
相关论文
共 50 条
  • [1] 4′-C-nucleoside derivatives: Synthesis and antiviral properties
    L. A. Alexandrova
    Russian Journal of Bioorganic Chemistry, 2011, 37 : 651 - 671
  • [2] Nucleoside Analogues: Synthesis and Biological Properties of Azanucleoside Derivatives
    Hernandez, Dacil
    Boto, Alicia
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 2014 (11) : 2201 - 2220
  • [3] A Concise Synthesis of Novel Aryl Pyrimidine C-Nucleoside Analogs from Sugar Alkynes
    Zhang, Fuyi
    Liang, Yan
    Li, Jing
    Gao, Fei
    Liu, Hong
    Zhao, Yufen
    ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 6 (05) : 561 - 565
  • [4] Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs
    Dentmon, Zackery W.
    Kaiser, Thomas M.
    Liotta, Dennis C.
    MOLECULES, 2020, 25 (21):
  • [5] Synthesis and biological properties of pyrimidine 4'-fluoronucleosides and 4'-fluorouridine 5'-O-triphosphate
    Ivanov, M. A.
    Ludva, G. S.
    Mukovnya, A. V.
    Kochetkov, S. N.
    Tunitskaya, V. L.
    Alexandrova, L. A.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2010, 36 (04) : 488 - 496
  • [6] Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action
    Zenchenko, A. A.
    Drenichev, M. S.
    Il'icheva, I. A.
    Mikhailov, S. N.
    MOLECULAR BIOLOGY, 2021, 55 (06) : 786 - 812
  • [7] SYNTHESIS AND ANTIVIRAL EVALUATION OF 4′-C-AZIDOMETHYL-β-D-RIBOFURANOSYL PURINE AND PYRIMIDINE NUCLEOSIDES
    Griffon, Jean-Francois
    Dumas, Audrey
    Storer, Richard
    Sommadossi, Jean-Pierre
    Gosselin, Gilles
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2009, 28 (5-7) : 435 - 449
  • [8] Synthesis of racemic 2-hydroxy-4-and 2-hydroxy-5-(hydroxymethyl)cyclohexane pyrimidine C-nucleoside analogues
    Sála, M
    Hrebabecky, H
    Masojídková, M
    Holy, A
    COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2004, 69 (04) : 918 - 932
  • [9] Improved Synthesis of a Salicylic Aldehyde C-Nucleoside for Metallo Base Pairs via Heck Reaction
    Minuth, Marco
    Frey, Wolfgang
    Richert, Clemens
    SYNLETT, 2014, 25 (10) : 1438 - 1442
  • [10] One-Pot Synthesis of Aryl Pyrazole C-Nucleoside Analogs of Pyrazofurin from Sugar Alkynes
    Liu, Hong
    Liang, Yan
    Jia, Tong-Tong
    Han, Fen
    Zhang, Fuyi
    Zhao, Yufen
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 2017 (11) : 1443 - 1449
12345