Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?

被引：32

作者：

Jackson, Malcolm J. ^{[1
]}

Stretton, Clare ^{[1
]}

McArdle, Anne ^{[1
]}

机构：

[1] Univ Liverpool, Inst Ageing & Chron Dis, MRC Arthrit Res UK Ctr Integrated Res Musculoskel, Liverpool L87TX, Merseyside, England

来源：

REDOX BIOLOGY | 2020年 / 35卷

基金：

英国医学研究理事会;

关键词：

NF-KAPPA-B; PROTEIN-TYROSINE PHOSPHATASES; INDUCED OXIDATIVE STRESS; REACTIVE OXYGEN; REDOX-REGULATION; FREE-RADICALS; VITAMIN-E; CONTRACTILE ACTIVITY; CELLULAR MECHANISMS; ADAPTIVE RESPONSES;

D O I：

10.1016/j.redox.2020.101484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol groups on “redox-sensitive” signalling proteins is unlikely to occur. A number of potential mechanisms have been proposed to explain how cells overcome this block to hydrogen peroxide-stimulated redox signalling and these will be discussed in the context of the redox-stimulation of specific adaptations of skeletal muscle to contractile activity and exercise. It is argued that current data implicate a role for currently unidentified effector molecules (likely to be highly reactive peroxidases) in propagation of the redox signal from sites of hydrogen peroxide generation to common adaptive signalling pathways. © 2020

引用

页数：5

共 58 条

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