Photophysical and photochemical studies of a novel amphiphilic zinc phthalocyanine and its interaction with calf thymus DNA

被引：12

作者：

Yuan, Linxin ^{[1
]}

Gui, Li ^{[1
]}

Wang, Yue ^{[1
]}

Zhang, Quanquan ^{[1
]}

Zhou, Lin ^{[1
]}

Wei, Shaohua ^{[1
]}

机构：

[1] Nanjing Normal Univ, Key Lab Appl Photochem, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Key Lab Biomed Mat,Sch Chem & Mat Sci,Anal & Test, Nanjing 210023, Jiangsu, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2016年 / 158卷

基金：

中国国家自然科学基金;

关键词：

Amphiphilic; Zinc phthalocyanine; Reactive oxygen species; CT-DNA; Photodynamic activity; ETHIDIUM BROMIDE INTERCALATION; FREE-RADICAL ATTACK; PHOTODYNAMIC THERAPY; SINGLET OXYGEN; ANTICANCER ACTIVITY; FLUORESCENCE; BINDING; PHOTOSENSITIZERS; SENSITIZERS; INHIBITION;

D O I：

10.1016/j.saa.2016.01.011

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

beta-tetra (aminophenoxy) sulfonic substituted zinc phthalocyanines (SNZnPc), a novel amphiphilic zinc phthalocyanine (Pc), was synthesized. The photophysical, photochemical, and photobiology properties were studied. Results indicated that the synthesized SNZnPc has good amphiphilic property and high reactive oxygen species (ROSs) generation ability. Furthermore, SNZnPc has strong affinity to calf thymus DNA (CT-DNA) through intercalation ways and can effectively cleavage CT-DNA after irradiation by light with appropriate wavelength. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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