The activity of class I, II, III and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in cervical cancer

被引：14

作者：

Orywal, Karolina ^{[1
]}

Jelski, Wojciech ^{[1
]}

Zdrodowski, Michal ^{[2
]}

Szmitkowski, Maciej ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Biochem Diagnost, PL-15276 Bialystok, Poland

[2] Med Univ Bialystok, Dept Gynecol, PL-15276 Bialystok, Poland

来源：

CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 14-15期

关键词：

Alcohol dehydrogenase isoenzymes; Aldehyde dehydrogenase; Cervical cancer; ADH ISOENZYMES; ALDH; DIFFERENTIATION; EXPRESSION; RETINOIDS; ISOZYMES; WOMEN;

D O I：

10.1016/j.clinbiochem.2011.07.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: The aim of this study was to compare the metabolism of cervical cancer cells and normal cervical cells by measurement of ADH isoenzymes and ALDH activities. Methods: The study material consisted of 40 cancerous cervical tissues. Class III, IV of ADH and total ADH activity was measured by the photometric method and class I, II ADH and ALDH activity by the fluorometric method with class-specific fluorogenic substrates. Results: The activity of the class I ADH isoenzyme and the total ADH were significantly higher in cervical cancer as compared to healthy tissues. Class I of ADH and total ADH activity are significantly higher in every stage of cancer as compared to the control. There are no significant differences between planoepitheliale and adenocarcinoma. Conclusion: The increased activity of total ADH in cervical cancer may be the cause of some metabolic disorders in cancer cells, which may intensify carcinogenesis in this organ. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1231 / 1234

页数：4

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