Chirality-based Au@Ag Nanorod Dimers Sensor for Ultrasensitive PSA Detection

被引：88

作者：

Tang, Lijuan ^{[1
]}

Li, Si ^{[1
]}

Xu, Liguang ^{[1
]}

Ma, Wei ^{[1
]}

Kuang, Hua ^{[1
]}

Wang, Libing ^{[1
]}

Xu, Chuanlai ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 23期

关键词：

Au@Ag nanorod dimers; chirality; PSA detection; PROSTATE-SPECIFIC ANTIGEN; CIRCULAR-DICHROISM; GOLD NANORODS; DNA DETECTION; ASSEMBLIES; CANCER; PLATFORM;

D O I：

10.1021/acsami.5b01259

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A novel biosensor for ultrasensitive detection of prostate-specific antigen (PSA) was established based on gold nanorod (Au NR) dimers assembly. The circular dichroism signal was significantly amplified by a silver shell depositing on the surface of the Au NR dimers. A low limit of detection of 0.076 aM and high specificity were observed within the range of 0.1 to 50 aM target PSA. The developed biosensor has the potential to serve as a general platform for the detection of cancer biomarkers.

引用

页码：12708 / 12712

页数：5

共 24 条

[1] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[2] Enzyme-responsive nanoparticles for drug release and diagnostics [J].

de la Rica, Roberto ;

Aili, Daniel ;

Stevens, Molly M. .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (11) :967-978

[3] Plasmonic Circular Dichroism of Chiral Metal Nanoparticle Assemblies [J].

Fan, Zhiyuan ;

Govorov, Alexander O. .

NANO LETTERS, 2010, 10 (07) :2580-2587

[4]

Fenner A, 2012, NAT REV UROL, V9, P473, DOI [10.1038/nrurol.2012.13, 10.1038/nrurol.2012.119, 10.1038/nrurol.2012.139, 10.1038/nrurol.2012.126, 10.1038/nrurol.2012.190, 10.1038/nrurol.2012.168]

[5] Plasmon-Induced Circular Dichroism of a Chiral Molecule in the Vicinity of Metal Nanocrystals. Application to Various Geometries [J].

Govorov, Alexander O. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (16) :7914-7923

[6]

GRAVES HCB, 1992, CLIN CHEM, V38, P735

[7] Chiral supernanostructures for ultrasensitive endonuclease analysis [J].

Hao, Changlong ;

Kuang, Hua ;

Xu, Liguang ;

Liu, Liqiang ;

Ma, Wei ;

Wang, Libing ;

Xu, Chuanlai .

JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (41) :5539-5542

[8] Biosensor developments: application to prostate-specific antigen detection [J].

Healy, Declan A. ;

Hayes, Conor J. ;

Leonard, Paul ;

McKenna, Louise ;

O'Kennedy, Richard .

TRENDS IN BIOTECHNOLOGY, 2007, 25 (03) :125-131

[9] Fabrication of chiral plasmonic oligomers using cysteine-modified gold nanorods as monomers [J].

Hou, Shuai ;

Wen, Tao ;

Zhang, Hui ;

Liu, Wenqi ;

Hu, Xiaona ;

Wang, Rongyao ;

Hu, Zhijian ;

Wu, Xiaochun .

NANO RESEARCH, 2014, 7 (11) :1699-1705

[10] Organic electrochemical transistor based immunosensor for prostate specific antigen (PSA) detection using gold nanoparticles for signal amplification [J].

Kim, Duck-Jin ;

Lee, Nae-Eung ;

Park, Joon-Shik ;

Park, In-Jun ;

Kim, Jung-Gu ;

Cho, Hyoung J. .

BIOSENSORS & BIOELECTRONICS, 2010, 25 (11) :2477-2482

← 1 2 3 →