Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica

被引：74

作者：

Chinworrungsee, M

Kittakoop, P

Isaka, M

Rungrod, A

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Bangkok 10400, Thailand

[2] Mahidol Univ, Dept Chem, Fac Sci, Bangkok 10400, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)00327-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halarosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC50 values of 1-13 mug/mL, while compounds 2, 3, 5. and 6 showed antimalarial activity with respective IC50 values of 17, 4, 13, and 19 mug/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 mug/mL. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1965 / 1969

页数：5

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