Advances in intravesical drug delivery systems to treat bladder cancer

被引：64

作者：

Kolawole, Oluwadamilola M. ^{[1
]}

Lau, Wing Man ^{[1
]}

Mostafid, Hugh ^{[2
]}

Khutoryanskiy, Vitaliy V. ^{[1
]}

机构：

[1] Univ Reading, Reading Sch Pharm, POB 224, Reading RG6 6AD, Berks, England

[2] Royal Surrey Cty Hosp, Dept Urol, Guildford, Surrey, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2017年 / 532卷 / 01期

关键词：

Bladder cancer; Intravesical drug delivery; Particulate delivery systems; In situ gelling systems; Mucoadhesive; Floating; THERMOSENSITIVE CHITOSAN HYDROGELS; DEACETYLASE INHIBITOR BELINOSTAT; CELL-PENETRATING PEPTIDES; BLOCK-COPOLYMER HYDROGELS; IN-VIVO EVALUATION; ARTIFICIAL URINE; GLYCEROPHOSPHATE HYDROGEL; SUSTAINED DELIVERY; CONTROLLED-RELEASE; HYDROPHOBIC DRUG;

D O I：

10.1016/j.ijpharm.2017.08.120

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemotherapeutic agents administered intravesically to treat bladder cancer have limited efficacy due to periodic dilution and wash-out during urine formation and elimination. This review describes the pathophysiology, prevalence and staging of bladder cancer, and discusses several formulation strategies used to improve drug residence within the bladder. These include the use of amphiphilic copolymers, mucoadhesive formulations, hydrogels, floating systems, and liposomes. Various in vitro and in vivo models recently employed for intravesical drug delivery studies are discussed. Some of the challenges that have prevented the clinical use of some promising formulations are identified.

引用

页码：105 / 117

页数：13

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