Novel drug-delivery approaches to the blood-brain barrier

被引：10
作者：
Wang, Xiaoqing [1 ,2 ]
Yu, Xiaowen [3 ]
Vaughan, William [4 ]
Liu, Mingyuan [1 ]
Guan, Yangtai [1 ]
机构：
[1] Second Mil Med Univ, Changhai Hosp, Dept Neurol, Shanghai 200433, Peoples R China
[2] Second Mil Med Univ, Changhai Hosp, Stem Cells & Med Res Ctr, Shanghai 200433, Peoples R China
[3] Second Mil Med Univ, Changhai Hosp, Dept Gerontol, Shanghai 200433, Peoples R China
[4] Yale Univ, Dept Genet, New Haven, CT 06519 USA
来源：
NEUROSCIENCE BULLETIN | 2015年 / 31卷 / 02期
基金：
上海市自然科学基金;
关键词：
drug delivery; blood-brain barrier; nanoparticles; focused ultrasound; CENTRAL-NERVOUS-SYSTEM; MICROVASCULAR ENDOTHELIAL-CELLS; FOCUSED-ULTRASOUND; TUNNELING NANOTUBES; POLYBUTYLCYANOACRYLATE NANOPARTICLES; LOADED MICROBUBBLES; MEMBRANE NANOTUBES; BRADYKININ AGONIST; GLIOMA TREATMENT; TIGHT JUNCTIONS;
D O I：
10.1007/s12264-014-1498-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The blood-brain barrier (BBB) maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies.
引用
收藏
页码：257 / 264
页数：8
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