Synthesis and radical scavenger properties of novel spirochromenes derived from steroid sapogenins

被引：15

作者：

Ramos-Enriquez, Manuel A. ^{[1
]}

Medina-Campos, Omar N. ^{[1
]}

Pedraza-Chaverri, Jose ^{[1
]}

Iglesias-Arteaga, Martin A. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico

来源：

STEROIDS | 2015年 / 98卷

关键词：

Steroid sapogenins; Spirochromenes; Radical scavengers; Antioxidant activity; DPPH test; ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; SIDE-CHAIN; BF3-CENTER-DOT-ET2O; ACID; CEPHALOSTATINS; PEROXIDATION; CHEMISTRY; PRODUCTS;

D O I：

10.1016/j.steroids.2015.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tandem aldol condensation between steroid sapogenins and hydroxylated benzaldehydes afforded steroidal spirochromenes. Compounds that bear a phenolic hydroxyl group at position C-6', obtained by a reaction with 2,5-dihydroxybenzaldehyde, showed approximately 80% of maximal radical scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay at 288 nM. In contrast, the starting steroid sapogenins and the spirochromenes without a phenolic group in the side chain proved to be inactive. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：132 / 137

页数：6

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