Construction of pyrazole fused spiroketals by a (3+2) annulation reaction

被引：6

作者：

Zhang, Wande ^{[1
]}

Wei, Xingfu ^{[1
]}

Wang, Yue ^{[1
]}

Huang, Yue ^{[1
]}

Nawaz, Shah ^{[1
]}

Qu, Jingping ^{[1
]}

Wang, Baomin ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 19期

关键词：

DERIVATIVES; CYCLIZATION; MOIETY;

D O I：

10.1039/d2qo01001a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective (3 + 2) annulation process between 4-bromo pyrazolones and benzofuran-derived azadienes was developed. A series of novel pyrazole fused spiroketals were synthesized in the presence of a base. The process has the salient features of simple operation, mild conditions, and fast reaction rate. The asymmetric (3 + 2) annulation reaction was initially explored, and an optimal catalytic system was obtained. The applicability of a few substrates was investigated, highlighting the possibility of asymmetric catalytic synthesis of chiral pyrazole fused spiroketals.

引用

页码：5197 / 5204

页数：8

共 29 条

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