Hematopoiesis: An evolving paradigm for stem cell biology

被引：1788
作者：
Orkin, Stuart H. [1 ,2 ,3 ]
Zon, Leonard I. [1 ,2 ,3 ]
机构：
[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Stem Cell Inst, Boston, MA 02115 USA
[3] Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
CELL | 2008年 / 132卷 / 04期
关键词：
D O I：
10.1016/j.cell.2008.01.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation. Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes.
引用
收藏
页码：631 / 644
页数：14
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