Lactic acid as an invaluable green solvent for ultrasound-assisted scalable synthesis of pyrrole derivatives

被引：20

作者：

Wang, Shi-Fan ^{[1
]}

Guo, Chao-Lun ^{[1
]}

Cui, Ke-ke ^{[1
]}

Zhu, Yan-Ting ^{[1
]}

Ding, Jun-Xiong ^{[1
]}

Zou, Xin-Yue ^{[1
]}

Li, Yi-Hang ^{[1
]}

机构：

[1] Hainan Univ, Sch Ocean, Dept Pharm, Haikou 570228, Peoples R China

来源：

ULTRASONICS SONOCHEMISTRY | 2015年 / 26卷

基金：

美国国家科学基金会;

关键词：

Scalable Knorr condensation; Ultrasonic radiation; Bio-based solvent; Lactic acid; Pyrrole derivative; N-SUBSTITUTED PYRROLES; IONIC LIQUIDS; ONE-POT; 4-COMPONENT SYNTHESIS; EFFICIENT; CATALYST; IRRADIATION; CHEMISTRY; SULFATE;

D O I：

10.1016/j.ultsonch.2015.01.002

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Lactic acid has been used as a bin-based green solvent to study the ultrasound-assisted scale-up synthesis. We report here, for the first time, on the novel and scalable process for synthesis of pyrrole derivatives in lactic acid solvent under ultrasonic radiation. Eighteen pyrrole derivatives have been synthesized in lactic acid solvent under ultrasonic radiation and characterized by H-1 NMR, IR, ESI MS. The results show, under ultrasonic radiation, lactic acid solvent can overcome the scale-up challenges and exhibited many advantages, such as bio-based origin, shorter reaction time, lower volatility, higher yields, and ease of isolating the products. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：81 / 86

页数：6

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