Traditional Chinese medicine for precancerous lesions of gastric cancer: A review

被引：151
作者：
Xu, Weichao [1 ,2 ]
Li, Bolin [1 ,2 ]
Xu, Miaochan [3 ]
Yang, Tianxiao [3 ]
Hao, Xinyu [4 ]
机构：
[1] Hebei Hosp Tradit Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
[2] Hebei Key Lab Integrated Tradit Chinese & Western, Shijiazhuang 050011, Hebei, Peoples R China
[3] Hebei Univ Chinese Med, Shijiazhuang 050200, Hebei, Peoples R China
[4] Peking Univ Third Hosp, Beijing 100191, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 146卷
关键词：
Precancerous lesions of gastric cancer; Traditional Chinese medicine; Pattern differentiation; Formulas; Pharmacological mechanism; NF-KAPPA-B; CHRONIC ATROPHIC GASTRITIS; HELICOBACTER-PYLORI; TNF-ALPHA; EXPRESSION; PROTECTION; APOPTOSIS; ANGIOGENESIS; INFLAMMATION; TRANSITION;
D O I：
10.1016/j.biopha.2021.112542
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gastric cancer (GC) is the fifth most common type of cancer and the third leading cause of death due to cancer worldwide. The gastric mucosa often undergoes many years of precancerous lesions of gastric cancer (PLGC) stages before progressing to gastric malignancy. Unfortunately, there are no effective Western drugs for patients with PLGC. In recent years, traditional Chinese medicine (TCM) has been proven effective in treating PLGC. Classical TCM formulas and chemical components isolated from some Chinese herbal medicines have been administered to treat PLGC, and the main advantage is their comprehensive intervention with multiple approaches and multiple targets. In this review, we focus on recent studies using TCM treatment for PLGC, including clinical observations and experimental research, with a focus on targets and mechanisms of drugs. This review provides some ideas and a theoretical basis for applying TCM to treat PLGC and prevent GC.
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页数：12
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