Novel Vilsmeier-type methylenation for synthesis of dipyrazolylmethane derivatives using formamide or N-methylformamide

被引：12

作者：

Wong, Fung Fuh ^{[1
]}

Huang, Yu-Ying ^{[1
]}

机构：

[1] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan

来源：

TETRAHEDRON | 2011年 / 67卷 / 21期

关键词：

Vilsmeier-type reaction; Methylenation; Dipyrazolylmethane; Pyrazolone; Formylation; ONE-POT SYNTHESIS; NUCLEOPHILIC-SUBSTITUTION; (ALKOXYMETHYLENE)DIMETHYLAMMONIUM CHLORIDE; CYCLODEHYDRATION REACTION; REGIOSELECTIVE SYNTHESIS; CONVENIENT PROCEDURE; EFFICIENT SYNTHESIS; FACILE SYNTHESIS; HAACK REACTION; CYCLIZATION;

D O I：

10.1016/j.tet.2011.03.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Vilsmeier-type methylenation for synthesis of dipyrazolylmethanes was developed by reacting pyrazolones with formamide or N-methylformamide in the presence of phosphorous oxychloride POCl3 coupling agent. This method can efficiently provide a series of dipyrazolylmethane derivatives as the main products in excellent yields without the formylated products. Our experimental result was different with the classical Vilsmeier-type reaction. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：3863 / 3867

页数：5

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