Asymmetric conjugate addition of nitroalkanes to enones with a chiral α-aminophosphonate catalyst

被引：45

作者：

Malmgren, Marcus ^{[1
]}

Granander, Johan ^{[1
]}

Amedjkouh, Mohamed ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

来源：

TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 16期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2008.07.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral diethyl (2R)-tetrahydropyrro-2-ylphosphonate is an effective catalyst for the Michael addition of nitroalkanes to alpha,beta-unsaturated ketones. This Study revealed that the hydrate salt of this alpha-aminophosphonate was found to be a better catalytic species. Moderate to high enantioselectivities were achieved in reactions that tolerate various nitroalkanes and enones in the presence of low loading of both catalyst ( 10 mol %) and bulk base (25 mol %). (C) 2008 Published by Elsevier Ltd.

引用

页码：1934 / 1940

页数：7

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