Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil

被引：93
|
作者：
Leal Parente, Leila Maria [2 ]
Lino Junior, Ruy de Souza [1 ]
Faustino Tresvenzol, Leonice Manrique [2 ]
Vinaud, Marina Clare [1 ]
de Paula, Jose Realino [2 ]
Paulo, Neusa Margarida [3 ]
机构：
[1] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Dept Gen Pathol, BR-74605050 Goiania, Go, Brazil
[2] Univ Fed Goias, Fac Pharm, Lab Nat Prod, BR-74605220 Goiania, Go, Brazil
[3] Univ Fed Goias, Sch Vet, BR-74001970 Goiania, Go, Brazil
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷
关键词：
MARIGOLD; FLOWERS; ANGIOGENESIS; ESTERS; PLANTS;
D O I：
10.1155/2012/375671
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed that C. officinalis presented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.
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页数：7
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