Mycophenolate mofetil in primary central nervous system vasculitis

被引:34
作者
Salvarani, Carlo [1 ]
Brown, Robert D., Jr. [2 ]
Christianson, Teresa J. H. [3 ]
Huston, John, III [4 ]
Giannini, Caterina [5 ]
Miller, Dylan V. [5 ]
Muratore, Francesco [1 ]
Hunder, Gene G. [6 ]
机构
[1] Azienda Osped IRCCS Reggio Emilia, Unita Operat Reumatol, I-42100 Reggio Emilia, Italy
[2] Mayo Clin, Dept Neurol, Rochester, MN USA
[3] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA
[4] Mayo Clin, Dept Radiol, Rochester, MN USA
[5] Mayo Clin, Div Anat Pathol, Rochester, MN USA
[6] Mayo Clin, Div Rheumatol, Rochester, MN USA
关键词
Mycophenolate mofetil; Therapy; PCNSV; Vasculitis; ISOLATED ANGIITIS;
D O I
10.1016/j.semarthrit.2015.02.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:55 / 59
页数:5
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