Mycophenolate mofetil in primary central nervous system vasculitis

被引：34

作者：

Salvarani, Carlo ^{[1
]}

Brown, Robert D., Jr. ^{[2
]}

Christianson, Teresa J. H. ^{[3
]}

Huston, John, III ^{[4
]}

Giannini, Caterina ^{[5
]}

Miller, Dylan V. ^{[5
]}

Muratore, Francesco ^{[1
]}

Hunder, Gene G. ^{[6
]}

机构：

[1] Azienda Osped IRCCS Reggio Emilia, Unita Operat Reumatol, I-42100 Reggio Emilia, Italy

[2] Mayo Clin, Dept Neurol, Rochester, MN USA

[3] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA

[4] Mayo Clin, Dept Radiol, Rochester, MN USA

[5] Mayo Clin, Div Anat Pathol, Rochester, MN USA

[6] Mayo Clin, Div Rheumatol, Rochester, MN USA

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 2015年 / 45卷 / 01期

关键词：

Mycophenolate mofetil; Therapy; PCNSV; Vasculitis; ISOLATED ANGIITIS;

D O I：

10.1016/j.semarthrit.2015.02.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：55 / 59

页数：5

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