(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides:: Investigation of the in vivo wound-healing activity of related terpenoids

被引：63

作者：

Villegas, LF

Marçalo, A

Martin, J

Fernández, ID

Maldonado, H

Vaisberg, AJ

Hammond, GB ^{[1
]}

机构：

[1] Univ Massachusetts Dartmouth, Dept Chem & Biochem, N Dartmouth, MA 02747 USA

[2] Univ Peruana Cayetano Heredia, Dept Ciencias Fisiol, Lima 100, Peru

[3] Univ Peruana Cayetano Heredia, Dept Quim, Lima 100, Peru

[4] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo Ciencia & Tecnol, Lima 100, Peru

[5] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima 100, Peru

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 10期

关键词：

D O I：

10.1021/np0102859

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha -bisabolol (1) (ED50 155 mug/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha -bisabolol (2) and a-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).

引用

页码：1357 / 1359

页数：3

共 26 条

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ANTONIADES HN, 1995, DIABETES REV, V3, P129

[3] PRENYLATION IN ACIDIC MEDIUM OF (-)-LIMONENE AND (+)-LIMONENE - SYNTHESIS OF (-)-ALPHA-BISABOLOLS AND (+)-ALPHA-BISABOLOLS AND (-)-EPI-8-ALPHA-BISABOLOLS AND (+)-EPI-8-ALPHA-BISABOLOLS [J].