The effects of supplementation with vitamin D on inflammatory biomarkers, omentin, and vaspin in women with type 2 diabetes: A randomized double-blind placebo-controlled clinical trial

被引：8

作者：

Fazelian, Siavash ^{[1
]}

Paknahad, Zamzam ^{[1
]}

Khajehali, Leila ^{[2
]}

Kheiri, Soleiman ^{[3
,4
]}

Amani, Reza ^{[1
]}

机构：

[1] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Dept Clin Nutr, Esfahan, Iran

[2] Imam Ali Hosp Farokhshahr, Social Secur Org, Shahrekord, Iran

[3] Shahrekord Univ Med Sci, Sch Hlth, Dept Epidemiol, Shahrekord, Iran

[4] Shahrekord Univ Med Sci, Sch Hlth, Dept Biostat, Shahrekord, Iran

来源：

JOURNAL OF FOOD BIOCHEMISTRY | 2018年 / 42卷 / 06期

关键词：

diabetes; hs-CRP; Omentin; vaspin; vitamin D; women; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC CONTROL; ANXIETY; ADIPOCYTOKINE; ASSOCIATION; POPULATION; PREVALENCE; CALCIUM;

D O I：

10.1111/jfbc.12631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D-3(26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C-reactive protein (hs-CRP), Interleukin 10 (IL-10), vaspin, and omentin were measured at the baseline and after 16-weeks supplementation. Serum hs-CRP was reduced (p = 0.01) and IL-10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post-intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti-inflammatory biomarkers in diabetic patients.

引用

页数：9

共 52 条

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