Can blocking inflammation enhance immunity during aging?

被引：62

作者：

Chambers, Emma S. ^{[1
,2
]}

Akbar, Arne N. ^{[1
]}

机构：

[1] UCL, Div Infect & Immun, London, England

[2] Queen Mary Univ London, Blizard Inst, Ctr Immunobiol, 4 Newark St, London E1 2AT, England

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2020年 / 145卷 / 05期

基金：

英国医学研究理事会;

关键词：

Inflammaging; senescence; p38-MAP Kinase; senolytics; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; T-CELL RESPONSES; SENESCENT CELLS; SECRETORY PHENOTYPE; MICROBIOTA COMPOSITION; SYSTEMIC INFLAMMATION; COGNITIVE DECLINE; IN-VIVO; EXPRESSION;

D O I：

10.1016/j.jaci.2020.03.016

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Aging is a global burden, and the increase in life span does not increase in parallel with health span. Therefore, older adults are currently living longer with chronic diseases, increased infections, and cancer. A characteristic of aging is the presence of chronic low-grade inflammation that is characterized by elevated concentrations of IL-6, TNF-alpha, and C-reactive protein, which has been termed inflammaging. Previous studies have demonstrated that chronic inflammation interferes with T-cell response and macrophage function and is also detrimental for vaccine responses. This raises the question of whether therapeutic strategies that reduce inflammation may be useful for improving immunity in older adults. In this review we discuss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the mechanisms by which inflammation may inhibit immunity. Finally, we describe existing interventions that target inflammation that have been used to enhance immunity during aging.

引用

页码：1323 / 1331

页数：9

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