Modulation of the Blood-Brain Barrier for Drug Delivery to Brain

被引：43

作者：

Han, Liang ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis Res, Suzhou 215123, Peoples R China

来源：

PHARMACEUTICS | 2021年 / 13卷 / 12期

基金：

中国国家自然科学基金;

关键词：

blood-brain barrier modulation; tight junction; active efflux; transcytosis; drug delivery; P-GLYCOPROTEIN EXPRESSION; INDUCED UP-REGULATION; GLIOMA-BEARING RATS; BREAST-CANCER CELLS; TUMOR BARRIER; FOCUSED ULTRASOUND; ALZHEIMERS-DISEASE; BRADYKININ AGONIST; IN-VIVO; POTASSIUM CHANNELS;

D O I：

10.3390/pharmaceutics13122024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The blood-brain barrier (BBB) precisely controls brain microenvironment and neural activity by regulating substance transport into and out of the brain. However, it severely hinders drug entry into the brain, and the efficiency of various systemic therapies against brain diseases. Modulation of the BBB via opening tight junctions, inhibiting active efflux and/or enhancing transcytosis, possesses the potential to increase BBB permeability and improve intracranial drug concentrations and systemic therapeutic efficiency. Various strategies of BBB modulation have been reported and investigated preclinically and/or clinically. This review describes conventional and emerging BBB modulation strategies and related mechanisms, and safety issues according to BBB structures and functions, to try to give more promising directions for designing more reasonable preclinical and clinical studies.

引用

页数：19

共 191 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[2] Prostaglandin EN receptor agonist protects against acute neurotoxicity [J].

Ahmad, AS ;

Ahmad, M ;

de Brum-Fernandes, AJ ;

Doré, S .

BRAIN RESEARCH, 2005, 1066 (1-2) :71-77

[3] MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications [J].

Ahmed, Nabid ;

Gandhi, Dheeraj ;

Melhem, Elias R. ;

Frenkel, Victor .

FRONTIERS IN NEUROLOGY, 2021, 12

[4] A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome [J].

Alakbarzade, Vafa ;

Hameed, Abdul ;

Quek, Debra Q. Y. ;

Chioza, Barry A. ;

Baple, Emma L. ;

Cazenave-Gassiot, Amaury ;

Nguyen, Long N. ;

Wenk, Markus R. ;

Ahmad, Arshia Q. ;

Sreekantan-Nair, Ajith ;

Weedon, Michael N. ;

Rich, Phil ;

Patton, Michael A. ;

Warner, Thomas T. ;

Silver, David L. ;

Crosby, Andrew H. .

NATURE GENETICS, 2015, 47 (07) :814-+

[5]

Alonso A, 2015, FRONT NEUROL NEUROSC, V36, P106, DOI 10.1159/000366242

[6] HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin [J].

Andras, Ibolya E. ;

Eum, Sung Yong ;

Huang, Wen ;

Zhong, Yu ;

Hennig, Bernhard ;

Toborek, Michal .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2010, 43 (02) :232-243

[7] Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis [J].

Andreone, Benjamin J. ;

Chow, Brian Wai ;

Tata, Aleksandra ;

Lacoste, Baptiste ;

Ben-Zvi, Ayal ;

Bullock, Kevin ;

Deik, Amy A. ;

Ginty, David D. ;

Clish, Clary B. ;

Gu, Chenghua .

NEURON, 2017, 94 (03) :581-+

[8] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain [J].

Anraku, Y. ;

Kuwahara, H. ;

Fukusato, Y. ;

Mizoguchi, A. ;

Ishii, T. ;

Nitta, K. ;

Matsumoto, Y. ;

Toh, K. ;

Miyata, K. ;

Uchida, S. ;

Nishina, K. ;

Osada, K. ;

Itaka, K. ;

Nishiyama, N. ;

Mizusawa, H. ;

Yamasoba, T. ;

Yokota, T. ;

Kataoka, K. .

NATURE COMMUNICATIONS, 2017, 8

[9] Stereotactic modulation of blood-brain barrier permeability to enhance drug delivery [J].

Appelboom, Geoff ;

Detappe, Alexandre ;

LoPresti, Melissa ;

Kunjachan, Sijumon ;

Mitrasinovic, Stefan ;

Goldman, Serge ;

Chang, Steve D. ;

Tillement, Olivier .

NEURO-ONCOLOGY, 2016, 18 (12) :1601-1609

[10] Pericytes regulate the blood-brain barrier [J].

Armulik, Annika ;

Genove, Guillem ;

Mae, Maarja ;

Nisancioglu, Maya H. ;

Wallgard, Elisabet ;

Niaudet, Colin ;

He, Liqun ;

Norlin, Jenny ;

Lindblom, Per ;

Strittmatter, Karin ;

Johansson, Bengt R. ;

Betsholtz, Christer .

NATURE, 2010, 468 (7323) :557-U231

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