Slowing the translocation of single-stranded DNA by using nano-cylindrical passage self-assembled by amphiphilic block copolymers

被引：13

作者：

Yoshida, Hiroshi ^{[1
]}

Goto, Yusuke ^{[2
]}

Akahori, Rena ^{[2
]}

Tada, Yasuhiko ^{[1
]}

Terada, Shohei ^{[1
]}

Komura, Motonori ^{[3
,4
]}

Iyoda, Tomokazu ^{[4
]}

机构：

[1] Hitachi Ltd, Res & Dev Grp, Ctr Technol Innovat Mat, 7-1-1 Omika, Hitachi, Ibaraki 3191292, Japan

[2] Hitachi Ltd, Res & Dev Grp, Ctr Technol Innovat Healthcare, 1-280 Higashi Koigakubo, Kokubunji, Tokyo 1858601, Japan

[3] Numazu Natl Coll Technol, Dept Elect & Elect Engn, Shizuoka 108501, Japan

[4] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, 4259-R1-25 Suzukakedai, Yokohama, Kanagawa 2268503, Japan

来源：

NANOSCALE | 2016年 / 8卷 / 43期

关键词：

NANOPORES; LITHOGRAPHY; TRANSPORT; FILMS;

D O I：

10.1039/c6nr06575a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel approach to slow the translocation of single-stranded DNA (ssDNA) by employing polyethylene oxide (PEO) filled nano-cylindrical domains as transportation channels. DNA strands were demonstrated to electrophoretically translocate through PEO filled cylindrical domains with diameters of 2 and 9 nm, which were self-assembled by amphiphilic liquid crystalline block copolymers. The average translocation rate of ssDNA strands was effectively reduced to an order of 10 mu s per nucleotide, which was 1-2 orders slower than that attained by utilizing conventional solid-state nanopore devices.

引用

页码：18270 / 18276

页数：7

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