A short synthesis of (S)-2-(diphenylmethyl)pyrrolidine, a chiral solvating agent for NMR analysis

被引：56

作者：

Bailey, DJ ^{[1
]}

OHagan, D ^{[1
]}

Tavasli, M ^{[1
]}

机构：

[1] UNIV DURHAM,SCI LABS,DEPT CHEM,DURHAM DH1 3LE,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(96)00495-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A three step synthesis of (S)-2(diphenylmethyl)pyrrolidine 4 is described which allows its preparation on a large scale. The C-2 symmetric diamines 5 and 6 have been prepared from 4 and are attractive as potential ligands for asymmetric transformations. Pyrrolidine 4 has been assessed as a chiral solvating agent for the NMR analysis of chiral compounds. It emerges as a good CSA for carboxylic acids and some secondary alcohols. (C) 1997, Elsevier Science Ltd. All rights reserved.

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页码：149 / 153

页数：5

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