Vitamins for Cancer Prevention and Treatment: An Insight

被引:40
作者
Jain, A. [1 ]
Tiwari, A. [2 ]
Verma, A. [2 ]
Jain, S. K. [2 ]
机构
[1] GLA Univ, Inst Pharmaceut Res, NH-2,Mathura Delhi Rd, Mathura 281406, UP, India
[2] Dr Hari Singh Gour Cent Univ, Dept Pharmaceut Sci, Pharmaceut Res Projects Lab, Sagar 470003, MP, India
关键词
Vitamin; cancer; prevention; treatment; diet; metabolism; targeting; TARGETED CO-DELIVERY; PROSTATE-CANCER; BETA-CAROTENE; LUNG-CANCER; E TPGS; BREAST-CANCER; 1,25-DIHYDROXYVITAMIN D-3; ALPHA-TOCOPHEROL; MIXED MICELLES; COLON-CANCER;
D O I
10.2174/1566524018666171205113329
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Over a few decades a strong interlink between oxidative damage and cancer has been investigated by various scientists across the world on the basis of epidemiological observations of the effects of fruits and vegetables used in the diet for cancer patients. Primarily, Vitamin C, Vitamin D and Vitamin E are reported to be involved in the amelioration of side effects which occur in chemotherapy and radiation therapy of lungs, stomach, prostate, colorectal, gastric head and neck cancers. The vitamins acting as antioxidant adjuvants are found to have apoptotic and anti-angiogenesis potential as well as inhibitory effects against metastasis in cancer cells. This chapter explicitly discusses the key aspects concerned with the vitamins in relation to cancer prevention and treatment. It describes vitamins and their natural resources, role of vitamins in the body, and vitamins as prime ingredients in the diet and their effects on cancer biology with reference to recent research reports. Moreover, this paper also includes the emerging potential of pharmaceutical advances to enhance bioavailability of the vitamins to cancer patients with improved safety and efficacy. Clinicians and researchers must mull over the nutritional requirements of individual cancer patient so as to treat cancer and increase life expectancy.
引用
收藏
页码:321 / 340
页数:20
相关论文
共 178 条
[21]   Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation [J].
Dai, X ;
Yamasaki, K ;
Yang, LJ ;
Sayama, K ;
Shirakata, Y ;
Tokumara, S ;
Yahata, Y ;
Tohyama, M ;
Hashimoto, K .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (06) :1356-1364
[22]   Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles [J].
Dangi, Ruchi ;
Hurkat, Pooja ;
Jain, Ankit ;
Shilpi, Satish ;
Jain, Ashish ;
Gulbake, Arvind ;
Jain, Sanjay K. .
JOURNAL OF MICROENCAPSULATION, 2014, 31 (05) :479-487
[23]   To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery [J].
Danhier, Fabienne ;
Feron, Olivier ;
Preat, Veronique .
JOURNAL OF CONTROLLED RELEASE, 2010, 148 (02) :135-146
[24]   Dietary γ-Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ [J].
Das Gupta, Soumyasri ;
Sae-Tan, Sudathip ;
Wahler, Joseph ;
So, Jae Young ;
Bak, Min Ji ;
Cheng, Larry C. ;
Lee, Mao-Jung ;
Lin, Yong ;
Shih, Weichung Joe ;
Shull, James D. ;
Safe, Stephen ;
Yang, Chung S. ;
Suh, Nanjoo .
CANCER PREVENTION RESEARCH, 2015, 8 (09) :807-816
[25]   Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study [J].
de Munter, Leonie ;
Maasland, Denise H. E. ;
van den Brandt, Piet A. ;
Kremer, Bernd ;
Schouten, Leo J. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2015, 102 (02) :420-432
[26]  
DELUCA H, 1971, BIOCHEMISTRY-US, V10, P2935
[27]  
DeLuca HF, 2004, AM J CLIN NUTR, V80, p1689S, DOI 10.1093/ajcn/80.6.1689S
[28]  
DEVET HCW, 1989, ANTICANCER RES, V9, P145
[29]  
DIGIOVANNI J, 1990, CHEM CARCINOGENESIS, P159
[30]   Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: a critical commentary [J].
Dolara, Piero ;
Bigagli, Elisabetta ;
Collins, Andrew .
EUROPEAN JOURNAL OF NUTRITION, 2012, 51 (07) :769-781