Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines

被引：7

作者：

Berry, Sian S. ^{[1
]}

Jones, Simon ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Dainton Bldg,Brook Hill, Sheffield S3 7HF, S Yorkshire, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

LIPASE-CATALYZED TRANSESTERIFICATION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; CHEMOENZYMATIC SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ENZYMATIC RESOLUTION; ALPHA; EFFICIENT; HYDROGENATION;

D O I：

10.1039/d1ob01943k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral substituted pyrrolidines are key elements in various biologically active molecules and are therefore valuable synthetic targets. One traditional method towards enantiomerically pure compounds is the application of kinetic resolution. In this review, current KR methodology used in the synthesis of substituted pyrrolidines is surveyed, including enzymatic methods, cycloadditions and reduction of ketones.

引用

页码：10493 / 10515

页数：23

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