Takayasu arteritis and primary sclerosing cholangitis: A casual association or different phenotypes of the same disease

被引：0

作者：

Mulinacci, Giacomo ^{[1
,2
]}

Palermo, Andrea ^{[1
,2
]}

Cristoferi, Laura ^{[1
,2
]}

Invernizzi, Pietro ^{[1
,2
]}

Carbone, Marco ^{[1
,2
]}

机构：

[1] Univ Milano Bicocca, Dept Med & Surg, Ctr Autoimmune Liver Dis, Div Gastroenterol, Milan, Italy

[2] San Gerardo Hosp, European Reference Network Hepatol Dis ERN RARE L, Monza, Italy

来源：

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY | 2021年 / 4卷

关键词：

Primary sclerosing cholangitis; Takayasu arteritis; Vasculitis; Inflammatory bowel disease;

D O I：

10.1016/j.jtauto.2021.100124

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Takayasu arteritis and primary sclerosing cholangitis are two rare disorders. The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. Conversely, the aetiology of primary sclerosing cholangitis remains elusive, even if dysimmunity seems to be one of the contributors to bile duct damage. Despite this, immunosuppressants do not alter disease course. In this paper we describe the association of these two rare disorders, with an unexpected normalization of cholestatic enzymes following steroid treatment. This might hint a novel subtype of sclerosing cholangitis with a prevalent immunebackground, or a local manifestation of Takayasu arteritis.

引用

页数：2

共 4 条

[1] On the Coexistence of Takayasu Arteritis and Inflammatory Bowel Disease [J].