Synthesis of 6-and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline

被引：2

作者：

Pham, Helen Trinh ^{[1
]}

Hanson, Robert N. ^{[1
]}

Olmsted, Sandra L. ^{[2
]}

Kozhushnyan, Anton ^{[1
]}

Visentin, Adam ^{[1
]}

Weglinsky, Paul J. ^{[1
]}

Massero, Chris ^{[1
]}

Bailey, Kristen ^{[1
]}

机构：

[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA

[2] Augsburg Coll, Dept Chem, Minneapolis, MN 55454 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 10期

关键词：

Anilinoquinazoline; Tyrosine kinase inhibitors; Bifunctional derivatives; TYROSINE KINASE INHIBITORS; COMBI-TARGETING CONCEPT; PYRROLOBENZODIAZEPINE DIMERS; ANTITUMOR-ACTIVITY; GEFITINIB IRESSA; CANCER-THERAPY; POTENT; DESIGN; ERLOTINIB; CYCLOADDITIONS;

D O I：

10.1016/j.tetlet.2010.11.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the novel isomeric 6- and 7-propargyloxy derivatives of 4-(3-fluoroanilino)-quinazoline was achieved using a six-step process. An alternate method to the 7-propargyloxy derivative and analogous 7-propargyloxy containing compounds is also described. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1053 / 1056

页数：4

共 50 条

[31] Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives
V. V. Odaryuk
N. I. Burakov
L. V. Kanibolotskaya
A. L. Kanibolotskii
I. D. Odaryuk
N. Yu. Lebedeva
E. N. Poddubnaya
A. N. Shendrik
Pharmaceutical Chemistry Journal, 2015, 49 : 96 - 98
[32] Synthesis and Antiradical and Antibacterial Activity of 4-(3',4'-Dihydroxyphenyl)Thiazole Derivatives
Odaryuk, V. V.
Burakov, N. I.
Kanibolotskaya, L. V.
Kanibolotskii, A. L.
Odaryuk, I. D.
Lebedeva, N. Yu.
Poddubnaya, E. N.
Shendrik, A. N.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (02) : 96 - 98
[33] COUMARIN SYNTHESIS .1. DERIVATIVES OF 4-(3',3'-DIMETILALILOXL)-CUMARINA
GONZALEZ, AG
CHICO, ED
JORGE, ZD
DORTA, HL
LUIS, FR
ANALES DE QUIMICA SERIE C-QUIMICA ORGANICA Y BIOQUIMICA, 1981, 77 (01): : 63 - 66
[34] Synthesis of 4-{[(4′-methyl-coumarin-7′-yl)amino]methyl}-coumarin derivatives
Kumar, K. Mahesh
Kotresh, O.
Ambekar, S. P.
Shirahatti, A. M.
Mahabaleshwaraiah, N. M.
Masuku, C. M.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2019, 58 (11): : 1252 - 1256
[35] SYNTHESIS OF 1,2-DISUBSTITUTED-5,6,7,8-TETRAHYDRO-4-QUINAZOLINE THIONES
TRIVEDI, JP
SHAH, RJ
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1976, 53 (09) : 952 - 953
[36] INDOLE DERIVATIVES .21. SYNTHESIS OF 4- AND 6-CHLOROINDOLEBUTYRIC ACIDS
SHAGALOV, LB
SOROKINA, NP
SUVOROV, NN
JOURNAL OF GENERAL CHEMISTRY USSR, 1964, 34 (05): : 1602 - &
[37] Synthesis and structure activity relationships of novel lincomycin derivatives. Part 4: synthesis of novel lincomycin analogs modified at the 6-and 7-positions and their potent antibacterial activities
Wakiyama, Yoshinari
Kumura, Ko
Umemura, Eijiro
Ueda, Kazutaka
Watanabe, Takashi
Yamada, Keiko
Okutomi, Takafumi
Ajito, Keiichi
JOURNAL OF ANTIBIOTICS, 2017, 70 (08): : 888 - 906
[38] Synthesis and biological properties of 4-(3H)-quinazolone derivatives
Tiwari, Aniani K.
Singh, Vinay Kumar
Bajpai, Aruna
Shukla, Gauri
Singh, Sweta
Mishra, Anil K.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (09) : 1234 - 1238
[39] Synthesis of a new heterocyclic system: Pyrazolo[3′,4′: 5,6][1,4]diazepino[7,1-b]quinazoline
S. V. Kemskii
E. V. Hrynyshyn
A. V. Bol’but
M. V. Vovk
Russian Journal of Organic Chemistry, 2016, 52 : 607 - 609
[40] Synthesis of a new heterocyclic system: Pyrazolo[3',4':5,6][1,4]diazepino[7,1-b]quinazoline
Kemskii, S. V.
Hrynyshyn, E. V.
Bol'but, A. V.
Vovk, M. V.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (04) : 607 - 609

← 1 2 3 4 5 →